{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:07:53Z","timestamp":1761988073895},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T00:00:00Z","timestamp":1138320000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The secondary lymphedema of the upper limb (post\u2010mastectomy lymphedema) has an incidence, in patients who underwent axillary lymphadenectomy for breast cancer, between 5 to 25%, up to 40% after radiotherapic treatment. We studied 50 patients treated for breast cancer. The patients were divided in two groups of 25 each, comparable for age, sex, pathology and treatment and followed up to 5 years after operation for breast. One group of 25 patients was controlled only clinically (physical examination, water volumetry) at 1\u20103\u20106 months and 1\u20103\u20105 years from breast cancer treatment. The other group of 25 patients was followed also by lymphatic scintigraphy performed pre\u2010operatively and after 1\u20103\u20106 months and 1\u20103\u20105 years from operation. In the first group, followed only clinically, lymphedema appeared in 9 patients after a period variable from 1 week to 2 years, with highest incidence between 3 and 6 months. In the second group of 25 patients, the preventive therapeutic protocol allowed to have a clinically evident arm lymphedema only in 2 patients. The comparison of the two groups of 25 patients proved a statistically significant difference in the appearance of arm secondary lymphedema (p = 0.01, using Fisher's exact test). The diagnostic and therapeutic preventive procedures allow to reduce the incidence rate of lymphedema significantly, in comparison with patients who did not undergo this protocol of prevention. \u00a9 2006 Wiley\u2010Liss, Inc. Microsurgery 26: 70\u201372, 2006.<\/jats:p>","DOI":"10.1002\/micr.20215","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T22:16:25Z","timestamp":1138400185000},"page":"70-72","source":"Crossref","is-referenced-by-count":20,"title":["Is there a role for microsurgery in the prevention of arm lymphedema secondary to breast cancer treatment?"],"prefix":"10.1002","volume":"26","author":[{"given":"C.","family":"Campisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Davini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fulcheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Da Rin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Eretta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Boccardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,27]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"27","article-title":"Il linfedema: aspetti attuali di diagnosi e terapia","volume":"1","author":"Campisi C","year":"1997","journal-title":"Flebol Oggi"},{"key":"e_1_2_1_3_2","first-page":"112","article-title":"Il linfedema dell'arto superiore secondario a linfoadenectomia e radioterapia adiuvante per cancro della mammella","volume":"3","author":"Campisi C","year":"1997","journal-title":"Osp Ital Chir"},{"key":"e_1_2_1_4_2","first-page":"84","article-title":"The diagnosis and treatment of peripheral lymphedema","volume":"36","author":"Consensus document of the International Society of Lymphology","year":"2003","journal-title":"Lymphology"},{"key":"e_1_2_1_5_2","first-page":"151","article-title":"On the pathophysiology of arm lymphodema after treatment for breast cancer","volume":"28","author":"F\u00f6ldi M","year":"1995","journal-title":"Lymphology"},{"key":"e_1_2_1_6_2","first-page":"47","article-title":"Role of microsurgery in management of lymphedema","volume":"18","author":"Campisi C","year":"1999","journal-title":"Int Angiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920160706"},{"key":"e_1_2_1_8_2","first-page":"11","article-title":"Lymphatic microsurgery: legend or reality?","volume":"7","author":"Campisi C","year":"1994","journal-title":"Phlebolymphology"},{"key":"e_1_2_1_9_2","first-page":"36","article-title":"Microsurgical treatment of peripheral lymphedema: an overview upon 25 years' clinical experience","volume":"26","author":"Campisi C","year":"1997","journal-title":"Eur J Lymphol Rel Probl"},{"key":"e_1_2_1_10_2","first-page":"110","article-title":"Linfedema dell'arto superiore secondario a trattamento per cancro della mammella: moderni aspetti di prevenzione, diagnosi e terapia microchirurgica","volume":"2","author":"Campisi C","year":"1998","journal-title":"Clin Chir Microchir"},{"key":"e_1_2_1_11_2","first-page":"562","article-title":"Post\u2010surgical lymphedema: iatrogenic or pre\u2010existing disease?","volume":"31","author":"Dellach\u00e0 A","year":"1998","journal-title":"Lymphology [Suppl]"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.20215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T03:47:00Z","timestamp":1694576820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.20215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/micr.20215"],"URL":"https:\/\/doi.org\/10.1002\/micr.20215","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}