{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:34:15Z","timestamp":1762004055635},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T00:00:00Z","timestamp":1192492800000},"content-version":"vor","delay-in-days":288,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are several differences between red and white muscles submitted to different experimental conditions, especially following denervation: a) denervation atrophy is more pronounced in red than white muscles; b) the size of the fibers in the red muscles does not vary between different parts of the muscle before and after denervation, when compared to white muscles; c) the regional difference in the white muscles initially more pronounced after denervation than red muscle; d) red muscle fibers and fibers of the deep white muscle present degenerative changes such as disordered myofibrils and sarcolemmal folds after long\u2010term denervation; e) myotube\u2010like fibers with central nuclei occur in the red muscle more rapidly than white after denervation. Denervation of skeletal muscles causes, in addition to fibers atrophy, loss of fibers with subsequent regeneration, but the extent of fat cell percentage invasion is currently unknown. The present article describes a quantitative study on fat cell invasion percentage in red m. soleus and white m. extensor digitorum longus (EDL) rat muscles at 7 weeks for up to 32 weeks postdenervation. The results indicate that the percentage of fat cells increase after denervation and it is steeper than the age\u2010related fat invasion in normal muscles. The fat percentage invasion is more pronounced in red compared with white muscle. All experimental groups present a statistically significant difference as regard fat cell percentage invasion. \u00a9 2007 Wiley\u2010Liss, Inc. Microsurgery, 2007.<\/jats:p>","DOI":"10.1002\/micr.20428","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T23:46:59Z","timestamp":1192578419000},"page":"664-667","source":"Crossref","is-referenced-by-count":15,"title":["Fat cell invasion in long\u2010term denervated skeletal muscle"],"prefix":"10.1002","volume":"27","author":[{"given":"Antonio de Castro","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus Carlos","family":"Andreo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo Marco Rosa","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00edcolas Bertolaccini","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Henrique Rapucci","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto P.","family":"Lauris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232832"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802857"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092430405"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209039"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092080203"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221079"},{"key":"e_1_2_1_8_2","first-page":"205","article-title":"Fibre types of M. pectineus of the cat (Felis domestica)","volume":"171","author":"Rodrigues AC","year":"1990","journal-title":"Anat Anz"},{"key":"e_1_2_1_9_2","first-page":"1","article-title":"Distribution of fibre types and fibre sizes in the tibialis cranialis muscle of beagle dogs","volume":"160","author":"Newsholme SJ","year":"1988","journal-title":"J Anat"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.2.433"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(02)00220-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01187235"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20428","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.20428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:12:40Z","timestamp":1700028760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.20428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/micr.20428"],"URL":"https:\/\/doi.org\/10.1002\/micr.20428","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}