{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:16:54Z","timestamp":1780064214261,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T00:00:00Z","timestamp":1203379200000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this experiment was to study the recording and stimulating properties, and biocompatibility of longitudinally implanted intrafascicular electrodes (LIFEs) in a rabbit sciatic nerve model when they were chronically implanted into peripheral fascicles. LIFEs were implanted chronically into sciatic nerve fascicles of rabbits as recording and stimulating electrodes. Motor\u2010evoked potentials (MEPs) and cortical somatosensory\u2010evoked potentials (CSEPs) were recorded by using a transcranial stimulation system (TCS) over 6\u2010month period to observe the change of the signals recorded. At the end of the experiment, the fascicles at the electrodes implanted site were anatomized for histological examination under light microscope and transmission electron microscope. Results showed onset latency (OL) of MEPs and CSEPs had no obvious change during the first month. However, OL significantly increased during the second month, and then became stable 3 months after implantation. The interpeak amplitudes (IPAs) of MEPs had no distinct change during the first month, but significantly decreased over the next period, and then became stable 3 months after implantation. The IPAs of CSEPs, however, decreased slowly over the 6\u2010month period of the study. At the end of the experiment, histological examination indicated that a typical foreign body reaction developed, and electrodes caused mild damage to the fascicles, though inflammatory cells and neuroma were not seen around the electrodes. In conclusion, LIFEs have excellent recording and stimulating characters in addition to biocompatibility with peripheral fascicles. They can be implanted chronically into fascicles and record signals. \u00a9 2008 Wiley\u2010Liss, Inc. Microsurgery, 2008.<\/jats:p>","DOI":"10.1002\/micr.20465","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T04:16:33Z","timestamp":1203480993000},"page":"203-209","source":"Crossref","is-referenced-by-count":13,"title":["Recording and stimulating properties of chronically implanted longitudinal intrafascicular electrodes in peripheral fascicles in an animal model"],"prefix":"10.1002","volume":"28","author":[{"given":"Xiujun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368058"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.10116"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.481986"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677308989075"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1302\/0301-620X.60B4.711808","article-title":"Clinical application study of multifunctional prosthetic hands","volume":"60","author":"Herberts P","year":"1978","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(05)80278-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1302\/0301-620X.67B2.3980541","article-title":"Electronically powered prostheses for the adult with an upper limb amputation","volume":"67","author":"Heger H","year":"1985","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/03093648809079390","article-title":"Traumatic amputation of the upper limb: the use of body\u2010powered prostheses and employment consequences","volume":"12","author":"Sturup J","year":"1988","journal-title":"Prosthet Orthot Int"},{"key":"e_1_2_1_10_2","first-page":"51","article-title":"Clinical application study of externally powered upper limb prosthetics system: The VA elbow, the VA hand, and the VA\/NU myoelectric hand system","volume":"11","author":"Lewis EA","year":"1975","journal-title":"Bull Prosthet Res"},{"key":"e_1_2_1_11_2","first-page":"683","article-title":"Therapeutic effect of NGF and GM01 on spinal cord ischemic injury","volume":"21","author":"Liu Y","year":"1999","journal-title":"Acta Acad Med Mil Tert"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199705010-00012"},{"key":"e_1_2_1_13_2","first-page":"254","article-title":"Somatosensory evoked potential evalution of acute nerve injury associated with external fixation procedures","volume":"308","author":"Marina RW","year":"1994","journal-title":"Clin Orthoped Relat Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(97)00025-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.243412"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368469"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.83604"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(96)00111-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1114\/1.35"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10303"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.886617"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20465","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.20465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:51:06Z","timestamp":1699959066000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.20465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/micr.20465"],"URL":"https:\/\/doi.org\/10.1002\/micr.20465","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}