{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:06:27Z","timestamp":1788566787504,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T00:00:00Z","timestamp":1222905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Much has been learned over the past several decades regarding thrombophilic conditions. Thrombotic complications, such as deep venous thrombosis, pulmonary embolus, myocardial infarction, and stroke, are sometimes attributed to a diagnosable thrombophilia. Less has been written with regard to their effect on reconstructive outcomes. Fortunately, it is rare to encounter a notable intraoperative thrombophilia while performing reconstructive microsurgery. When this does occur, salvage can be difficult and outcome can be compromised. It is imperative that microsurgeons be knowledgeable of both major and minor thrombogenic conditions to optimize intraoperative outcome and postoperative care. We present a case of a failed free flap for lower extremity reconstruction associated with hyperhomocysteinemia in conjunction with markedly elevated Factor VIII levels. \u00a9 2008 Wiley\u2010Liss, Inc. Microsurgery, 2009.<\/jats:p>","DOI":"10.1002\/micr.20553","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T15:55:29Z","timestamp":1222962929000},"page":"62-65","source":"Crossref","is-referenced-by-count":13,"title":["Free flap failure secondary to dual thrombophilia"],"prefix":"10.1002","volume":"29","author":[{"given":"Michael Robert","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Daniel Huff","family":"Shell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Neal","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,2]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Phlogose und Thrombose im gef\u00e4\u03b2system: Gesammelte Abhandlungen zur Wissenschaftlichen Medizin","author":"Virchow R","year":"1856"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698"},{"key":"e_1_2_1_5_2","first-page":"516","article-title":"Inherited antithrombin III deficiency causing thrombophilia","volume":"13","author":"Egeberg O","year":"1965","journal-title":"Thromb Diath Haemorrh"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110385"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V64.6.1297.1297"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.5.731"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1055\/s-0038-1642511","article-title":"Factor VII and fibrinogen levels as risk factors for venous thrombosis: A case\u2010control study of plasma levels and DNA polymorphisms: The Leiden Thrombophilia Study (LETS)","volume":"71","author":"Koster T","year":"1994","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504133321504"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130055028"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341203"},{"key":"e_1_2_1_13_2","first-page":"473","article-title":"Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy","volume":"114","author":"Ueland P","year":"1989","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.12.070192.001431"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381507"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7374.1202"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613747"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365516209079703"},{"key":"e_1_2_1_19_2","first-page":"89","article-title":"Factor VIII and factor IX in a twin population: Evidence for a major effect of ABO locus on factor VIII level","volume":"37","author":"\u00d8rstavik K","year":"1985","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90166-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430702"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000157640.70913.AA"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199806000-00011"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-005-0783-1"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20553","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.20553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:54:53Z","timestamp":1699923293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.20553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/micr.20553"],"URL":"https:\/\/doi.org\/10.1002\/micr.20553","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,2]]}}}