{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:29:47Z","timestamp":1758479387899},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T00:00:00Z","timestamp":1254182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Hungarian Scientific Research Fund","award":["OTKA K-67779O","TKA F-68323"],"award-info":[{"award-number":["OTKA K-67779O","TKA F-68323"]}]},{"name":"BILAT","award":["TR-03\/2006"],"award-info":[{"award-number":["TR-03\/2006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate intestinal ischemia\u2010reperfusion and its local and systemic hemorheological relations in the rat. Ten anaesthetized female CD outbred rats were equally divided into 2 experimental groups. (1) Ischemia\u2010reperfusion (I\/R): the superior mesenterial artery was clipped for 30 minutes. After removing the clip, 60 minutes of the reperfusion was observed before extermination. Blood samples were taken from the caudal caval vein and from the portal vein before ischemia, 1 minute before and after clip removal, and at the 15th, 30th, and 60th minutes of the reperfusion. (2) Sham operation: median laparotomy and blood sampling were done according to the timing as in I\/R group. Hematological parameters, red blood cell aggregation, and deformability were determined. Leukocyte count and mean volume of erythrocytes increased slightly but continuously in portal venous samples during the reperfusion period. Red blood cell aggregation values were higher in portal blood by the end of ischemia, and then became elevated further comparing to the caval venous blood. Both in caval and portal venous samples of I\/R group red blood cell deformability significantly worsened during the experimental period compared to its base and Sham group. In portal blood red blood cell deformability was impaired more than in caval vein samples. Histology showed denuded villi, dilated capillaries, and the inflammatory cells were increased after a 30 minutes ischemia. In conclusion, intestinal ischemia\u2010reperfusion causes changes in erythrocyte deformability and aggregation, showing local versus systemic differences in venous blood during the first hour of reperfusion. \u00a9 2009 Wiley\u2010Liss, Inc. Microsurgery, 2010.<\/jats:p>","DOI":"10.1002\/micr.20707","type":"journal-article","created":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T14:29:45Z","timestamp":1254234585000},"page":"321-326","source":"Crossref","is-referenced-by-count":9,"title":["Changes of local and systemic hemorheological properties in intestinal ischemia\u2010reperfusion injury in the rat 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