{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:40:50Z","timestamp":1792716050276,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T00:00:00Z","timestamp":1262563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Heart and Stroke Foundation of Ontario","award":["NA5938"],"award-info":[{"award-number":["NA5938"]}]},{"name":"Heart and Stroke Foundation of Ontario","award":["T6318"],"award-info":[{"award-number":["T6318"]}]},{"DOI":"10.13039\/501100001258","name":"Roche Organ Transplantation Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001258","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Kidney Foundation of Canada"},{"name":"Canada Foundation for Innovation"},{"name":"Lawson Health Research Institute Internal Research Funds and the Multi-Organ Transplant Program Research Grant"},{"name":"London Health Sciences Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously described a duodenojejunal bypass (DJB) surgical model in healthy C57BL\/6 mice. However, our pilot study showed that the same surgical technique caused a high mortality rate in obese mice. In this study, to significantly improve animal survival rate following bariatric surgery and thereby providing a stable surgical model for the study of glucose homeostasis in obese mice, we have used modified techniques and developed the end\u2010to\u2010side gastrojejunal bypass (GJB) surgery in obese C57BL\/6 with impaired glucose tolerance. The modification consisted of using the distal part of the jejunum for biliopancreatic diversion including: 1) ligation of the distal stomach at the level of the pylorus; 2) connection the jejunum to the anterior wall of stomach in an end\u2010to\u2010side fashion; and 3) diverting the biliopancreatic secretions through the blind limb into the distal jejunum through an end\u2010to\u2010side anastomosis. We found that by modifying the proximal end\u2010to\u2010end duodenojejunal anastomosis, described in our original model, to an end\u2010to\u2010side gastrojejunal anastomosis in these obese mice, we were able to significantly improve the postoperative mortality in this study. We have also demonstrated that performing the GJB surgery in obese mice resulted in significant weight loss, normalized blood glucose levels, and prevented acute pancreatitis. This newly developed GJB surgery in the obese mice offers a unique advantage to study the mechanisms of gastrointestinal surgery as treatment for type 2 diabetes. \u00a9 2010 Wiley\u2010Liss, Inc. Microsurgery, 2010.<\/jats:p>","DOI":"10.1002\/micr.20746","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T16:35:55Z","timestamp":1262622955000},"page":"289-295","source":"Crossref","is-referenced-by-count":12,"title":["Development of techniques for gastrojejunal bypass surgery in obese mice"],"prefix":"10.1002","volume":"30","author":[{"given":"Zhu","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Zassoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rennian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-4-199908170-00008"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.286"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921010-00002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.14.1724"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.041"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000137343.63376.19"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.06.014"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20454"},{"key":"e_1_2_1_10_2","first-page":"1","volume-title":"Guide to the Care and Use of Experimental Animals","author":"Olfert ED","year":"1993"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000102989.54824.fc"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000224726.61448.1b"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-009-9811-0"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20746","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.20746","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.20746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:26:37Z","timestamp":1700591197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.20746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/micr.20746"],"URL":"https:\/\/doi.org\/10.1002\/micr.20746","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,4]]}}}