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The first patient underwent a deep inferior epigastric artery perforator flap and then had recurrent arterial thrombosis both intraoperatively and postoperatively. This patient was subsequently diagnosed with a factor V Leiden mutation. The second patient had a known factor V Leiden mutation and underwent a superior gluteal artery perforator flap, which developed thrombosis and flap loss 2 days later. Preoperative assessment of a personal or family history of unexplained venous or arterial thrombosis should prompt suspicion of a factor V Leiden mutation. This mutation places patients at high risk for thromboembolic events in microvascular breast reconstruction, particularly when oral contraceptives or tamoxifen are used in conjunction. \u00a9 2011 Wiley\u2010Liss, Inc. Microsurgery, 2011.<\/jats:p>","DOI":"10.1002\/micr.20879","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T15:53:03Z","timestamp":1303141983000},"page":"409-412","source":"Crossref","is-referenced-by-count":20,"title":["Factor V Leiden associated with flap loss in microsurgical breast reconstruction"],"prefix":"10.1002","volume":"31","author":[{"given":"Ibrahim","family":"Khansa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih","family":"Colakoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Tomich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh\u2010Doan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard 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