{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:12:13Z","timestamp":1791231133999,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T00:00:00Z","timestamp":1332288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Introduction:<\/jats:italic><\/jats:title><jats:p>The aim of this study was to evaluate long\u2010term regenerative capacity over a 15\u2010mm nerve gap of an autologous nerve conduit, the biogenic conduit (BC), 16 weeks after sciatic nerve transection in the rat.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods<\/jats:italic>:<\/jats:title><jats:p>A 19\u2010mm long polyvinyl chloride (PVC) tube was implanted parallely to the sciatic nerve. After implantation, a connective tissue cover developed around the PVC\u2010tube, the so\u2010called BC. After removal of the PVC\u2010tube the BCs filled with fibrin (<jats:italic>n<\/jats:italic> = 8) were compared to autologous nerve grafts (<jats:italic>n<\/jats:italic> = 8). Sciatic functional index (SFI) was evaluated every 4 weeks, histological evaluation was performed at 16 weeks postimplantation. Regenerating axons were visualized by retrograde labelling.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results<\/jats:italic>:<\/jats:title><jats:p>SFI revealed no significant differences. Nerve area and axon number in the BC group were significantly lower than in the autologous nerve group (<jats:italic>P<\/jats:italic> &lt; 0.05; <jats:italic>P<\/jats:italic> &lt; 0.01). Analysis of myelin formation showed no significant difference in both groups. Analysis of <jats:italic>N<\/jats:italic>\u2010ratio revealed lower values in the BC group (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusion<\/jats:italic>:<\/jats:title><jats:p>This study reveals the suitability of BC for nerve gap bridging over a period of 16 weeks with functional recovery to comparable extent as the autologous nerve graft despite impaired histomorphometric parameters. \u00a9 2012 Wiley Periodicals, Inc. Microsurgery, 2012.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.21974","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T19:15:00Z","timestamp":1332443700000},"page":"377-382","source":"Crossref","is-referenced-by-count":20,"title":["The long\u2010term functional recovery of repair of sciatic nerve transection with biogenic conduits"],"prefix":"10.1002","volume":"32","author":[{"given":"Vincenzo","family":"Penna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Wewetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Munder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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