{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:11:33Z","timestamp":1773306693534,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present the case of a 40\u2010year\u2010old patient with sickle cell trait who underwent bilateral breast reconstruction with microvascular TRAM flap transfer. Intraoperatively, the patient developed arterial anastomotic thrombosis of the right breast flap. The left breast flap had already been harvested and was placed on ice. Both anastomoses were then successfully completed. Postoperatively, the patient developed a pulmonary embolism and heparin\u2010induced thrombocytopenia. On postoperative day 12, the left cutaneous Doppler signals were lost, and exploration revealed a thrombosed pedicle and nonviable left breast flap. Pathologic specimen evaluation revealed sickled cells within the flap microvasculature. We believe that prolonged ischemia time and hypothermia precipitated erythrocyte sickling within the flap, causing intra\u2010flap thrombosis that propagated to the pedicle. While sickle cell diseases are not a contraindication to free tissue transfer, we believe that flap cooling should be utilized with caution in this circumstance. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/micr.22024","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T13:49:07Z","timestamp":1347544147000},"page":"585-587","source":"Crossref","is-referenced-by-count":14,"title":["Intra\u2010flap thrombosis secondary to acute sickle crisis: A case report"],"prefix":"10.1002","volume":"32","author":[{"given":"Alison","family":"Mcanneny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Durden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,13]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00015"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181adcf35"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aec4d"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20879"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2006.12.007"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000072283.47341.43"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.12.020"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057604"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199209000-00017"},{"key":"e_1_2_4_11_2","first-page":"516","article-title":"Exchange transfusion for flap surgery in sickle cell anemia","volume":"23","author":"Ashbell TS","year":"1972","journal-title":"Surg Forum"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.2000.3446"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20739"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.22024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.22024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.22024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T14:04:49Z","timestamp":1696860289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.22024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,13]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/micr.22024"],"URL":"https:\/\/doi.org\/10.1002\/micr.22024","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,13]]}}}