{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:04:20Z","timestamp":1768975460163,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Orthopaedic Scientific Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Adipose tissue\u2010derived stem cells and insulin\u2010like growth factor\u20101 (IGF\u20101) have shown potential to enhance peripheral nerve regeneration. The purpose of this study was to investigate the effect of an in vivo biologic scaffold, consisting of white adipose tissue flap (WATF) and\/or IGF\u20101 on nerve regeneration in a crush injury model. Forty rats all underwent a sciatic nerve crush injury and then received: a pedicled WATF, a controlled local release of IGF\u20101, both treatments, or no treatment at the injury site. Outcomes were the normalized maximum isometric tetanic force (ITF) of the tibialis anterior muscle and histomorphometric measurements. At 4 weeks, groups with WATF had a statistically significant improvement in maximum ITF recovery, as compared to those without (P &lt; 0.05), and there was an increase in myelin thickness and total axon count in the WATF\u2010only group versus control (P &lt; 0.01). Functional and histomorphometric data suggest that IGF\u20101 suppressed the effect of the WATF. Use of a pedicled WATF improved the functional and histomorphometrical results after axonotmesis in a rat model. IGF\u20101 does not appear to enhance nerve regeneration in this model. Utilizing the WATF may have a beneficial therapeutic role in peripheral nerve injuries. \u00a9 2013 Wiley Periodicals, Inc. Microsurgery 33:367\u2013375, 2013.<\/jats:p>","DOI":"10.1002\/micr.22101","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T15:45:18Z","timestamp":1367941518000},"page":"367-375","source":"Crossref","is-referenced-by-count":23,"title":["Effect of white adipose tissue flap and insulin\u2010like growth factor\u20101 on nerve regeneration in rats"],"prefix":"10.1002","volume":"33","author":[{"given":"Ayhan","family":"Kilic","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bukola","family":"Ojo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Rajfer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Konopka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hagg","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Laboratory Columbia University College of Dental Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena","family":"Akelina","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy J.","family":"Mao","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Laboratory Columbia University College of Dental Medicine New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin P.","family":"Rosenwasser","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218810406003279"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2008.11.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2009.07.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.08.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368909788341289"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21895"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2009.12.019"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218810400000120"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(96)80201-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.03.035"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.11.021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f44790"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.036"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-833499"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2001.24148"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb26214.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013851"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(94)90007-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21485"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90531-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981215)54:6<840::AID-JNR12>3.0.CO;2-L"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.537"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.10039"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20520"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-108"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.03.014"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20941"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.05.028"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.12.033"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.21969"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000223233"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1410-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2007.11753967"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.54.132"},{"issue":"50","key":"e_1_2_6_37_1","first-page":"37","article-title":"Neural potential of adipose stem cells","volume":"10","author":"Zavan B","year":"2010","journal-title":"Discov Med"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200101000-00017"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632701300062859"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368909788341289"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00054-7"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.004"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002143020704"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2007.00240.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0218810499000319"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00257-1"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.9.JNS091928"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10165"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0273"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20869"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar9800993"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013798"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2008.08.010"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.22101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.22101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.22101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:47:32Z","timestamp":1696402052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.22101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/micr.22101"],"URL":"https:\/\/doi.org\/10.1002\/micr.22101","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]}}}