{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:05:17Z","timestamp":1769313917487,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>End\u2010to\u2010side (ETS) neurorrhaphy has been applied in the repair of peripheral nerve injuries and in babysitter procedures. However, the long\u2010term changes of donor nerve and muscle after ETS remain unknown. This study was designed to investigate long\u2010term changes in donor nerve and muscle in a rat model. Sixty Lewis rats were equally allocated into three groups of 20 rats. The peroneal nerve was divided. In Group A, end\u2010to\u2010end (ETE) neurorrhaphy was performed. In Group B, ETS was performed to an epineurial window on the tibial nerve. In Group C, ETS was performed to the tibial nerve with 40% partial neurectomy. The following data were obtained at 6, 12, 18, and 24 weeks postoperatively: latency delaying rate (LDR), amplitude recovery rate (ARR), myelinated fiber counts, muscle force and weight, and cross\u2010sectional area of gastrocnemius muscle fibers. The results showed no significant changes of the donor nerve and muscle in Group B. Nerve regeneration was found in the peroneal nerve, and myelinated fiber number was significantly decreased when compared to the nerve with ETE. In Group C, the myelinated axon number in the peroneal nerve was equivalent to the level in ETE repair. However, function and structure of the donor nerve and muscle were significantly impaired in the early postoperative period. Nonetheless, full recovery was observed 24 weeks after surgery. Both ETS with epineurial window and 40% donor nerve neurectomy showed reinnervation of the recipient nerve without structural and functional changes of the donor system in a long\u2010term follow\u2010up. Partial neurectomy may promote recipient nerve regeneration, but at the cost of donor neuromuscular compromises in the early postoperative period. This study provides long\u2010term evidence for further investigation of ETS in peripheral nerve repair and in babysitter procedures. \u00a9 2013 Wiley Periodicals, Inc. Microsurgery 34:136\u2013144, 2014.<\/jats:p>","DOI":"10.1002\/micr.22167","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T14:01:21Z","timestamp":1378476081000},"page":"136-144","source":"Crossref","is-referenced-by-count":11,"title":["Changes of the donor nerve in end\u2010to\u2010side neurorrhaphies with epineurial window and partial neurectomy: A long\u2010term evaluation in the rat model"],"prefix":"10.1002","volume":"34","author":[{"given":"Hai\u2010Fei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Zhongshan Hospital Fudan University Shanghai China"},{"name":"Department of Orthopedic Surgery, the Affiliated Hospital of Medical College Qingdao University Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng\u2010Gan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao\u2010Lin","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Zhongshan Hospital Fudan University Shanghai China"},{"name":"Division of Plastic Surgery University of Mississippi Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Arnold","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery University of Mississippi Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Lineaweaver","sequence":"additional","affiliation":[{"name":"JMS Burn and Reconstruction Center Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199807000-00025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v2.i11.102"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000208"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7538"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31819ba4bb"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/00006534-199412000-00019","article-title":"End\u2010to\u2010side neurorrhaphy with removal of the epineurial sheath: an experimental study in rats","volume":"94","author":"Viterbo F","year":"1994","journal-title":"Plast Reconstr Surg"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7338"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20861"},{"key":"e_1_2_5_10_1","first-page":"267","article-title":"Latero\u2010terminal neurorrhaphy without removal of the epineural sheath. 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