{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:43:15Z","timestamp":1766133795840},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Complications arising from anastomotic failure may occur after pharyngoesophageal reconstruction. In this report we present results of pharyngoesophageal reconstruction with free thigh flaps using a refined design and inset strategy in a series of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From May 2011 to December 2012, pharyngoesophageal oncologic defects were reconstructed in 12 men using thigh flaps. Flaps were designed to exceed defect circumference to allow draping of the excess over injury\u2010prone vessels (so\u2010called delta\u2010inset). Patients were 39\u2010 to 68\u2010years\u2010old (mean, 51.8\u2010years\u2010old) at the time of surgery. BMI ranged from 17 to 28 kg\/m<jats:sup>2<\/jats:sup> (average, 21.5 kg\/m<jats:sup>2<\/jats:sup>). The sites of defects were the hypopharynx in 11 cases and the pharynx in 1 case. Ten anterolateral thigh (ALT) flaps and 2 anteromedial thigh (AMT) flaps were used. All patients underwent radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average flap size was 22 \u00d7 9 cm (range: 16\u201326 \u00d7 7\u201311 cm<jats:sup>2<\/jats:sup>). There were no partial or total flap losses, and no donor site complications. Follow\u2010up was 19.3 months (range: 2.4\u201321.6 months) including 8 patients (75%) who succumbed to disease in the follow\u2010up period. Oral intake was achieved in all patients. Recipient site complications occurred in 50% of cases and included fistula (2 cases), fistula and stricture (2 cases), stricture (1 case), and lymphocele (1 case). Four patients required revision for fistula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A refined thigh flap design and inset method in pharyngoesophageal reconstruction may circumvent complications arising from toxic drainage and vascular injury. However, there are insufficient data to make meaningful comparisons to alternative methods. \u00a9 2015 Wiley Periodicals, Inc. Microsurgery 37:112\u2013118, 2017.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.22432","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T14:58:06Z","timestamp":1434725886000},"page":"112-118","source":"Crossref","is-referenced-by-count":22,"title":["Refinements in flap design and inset for pharyngoesophageal reconstruction with free thigh flaps"],"prefix":"10.1002","volume":"37","author":[{"given":"Jonathan A.","family":"Zelken","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Jan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiang\u2010Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Kan","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0094-1298(20)32724-3","article-title":"Reconstruction of the pharynx and cervical esophagus using free jejunal transfer","volume":"21","author":"Reece GP","year":"1994","journal-title":"Clin Plast Surg"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22223"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90313-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196508000-00004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197964050-00002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198504000-00001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22212"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22209"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.9.796"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2010.10.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182605400"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20489"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.12.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f95997"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.09.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24947"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000191179.58054.80"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000218248.22811.70"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199211000-00005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22359"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.09.030"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1376887"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23590"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(79)90429-X"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510011000X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2011.06.002"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197307000-00006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0775-3"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540940111"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998780860S408"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000046"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100136400"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32725-5"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040771"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09180"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21352"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197505000-00011"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860360049016"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198805000-00006"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199009000-00019"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181d0ab23"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199401000-00024"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000178042.26186.c1"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.22432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.22432","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.22432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:59:27Z","timestamp":1695571167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.22432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/micr.22432"],"URL":"https:\/\/doi.org\/10.1002\/micr.22432","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}