{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:26:09Z","timestamp":1776115569603,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>None of the existing treatments in the management of painful end\u2010neuromas of the superficial branch of the radial nerve (SBRN) has been proven superior due to high levels of pain relapse. Fat grafts enriched with the stromal vascular fraction (SVF) could act as a mechanic barrier with biological effects decreasing the resorption rate and boosting the graft's regenerative potential. This study describes the novel surgical treatment technique of SVF\u2010enriched fat grafting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In this clinical study, five consecutive patients treated for painful end\u2010neuromas of the SBRN between 2012 and 2013 were analyzed retrospectively. Microsurgical resection of end\u2010neuromas followed by SVF\u2010enriched fat grafting around the nerve stump was performed in all patients. Five different pain modalities and various predictors were compared pre\u2010 and up to 36\u00a0months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pain reduction observed at 2\u00a0months after surgery was constant over time, though not statistically significant compared to preoperative levels. Spontaneous pain could be reduced from 1.6\u00a0\u00b1\u00a00.55 to 1.2\u00a0\u00b1\u00a01.1 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.414), spikes from 2.2\u00a0\u00b1\u00a01.3 to 1.4\u00a0\u00b1\u00a01.34 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.180), hyperaesthesia from 1.6\u00a0\u00b1\u00a01.14 to 1.2\u00a0\u00b1\u00a01.64 (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.713), tap pain from 2.8\u00a0\u00b1\u00a00.45 to 1.8\u00a0\u00b1\u00a01.3 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.197) and motion pain from 2.8\u00a0\u00b1\u00a00.45 to 1.4\u00a0\u00b1\u00a01.34 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.066). An improvement in overall pain reduction could be observed from 2.2\u00a0\u00b1\u00a00.97 to 1.4\u00a0\u00b1\u00a01.26 3\u00a0years after the surgery (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SVF\u2010enriched fat grafting represents another alternative to numerous available treatments of painful end\u2010neuromas of the SBRN. Our preliminary results could not show any significant difference in pain reduction following SVF\u2010enriched fat grafting. Further larger trials are required in order to evaluate the therapeutic potential of SVF\u2010enriched fat grafting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30122","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T19:26:45Z","timestamp":1476386805000},"page":"264-269","source":"Crossref","is-referenced-by-count":19,"title":["The novel treatment of SVF\u2010enriched fat grafting for painful end\u2010neuromas of superficial radial nerve"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-0561","authenticated-orcid":false,"given":"Maurizio","family":"Calcagni","sequence":"first","affiliation":[{"name":"Division of Plastic and Hand Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Division of Plastic and Hand Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario F.","family":"Scaglioni","sequence":"additional","affiliation":[{"name":"Division of Plastic and Hand Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Giesen","sequence":"additional","affiliation":[{"name":"Division of Plastic and Hand Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Giovanoli","sequence":"additional","affiliation":[{"name":"Division of Plastic and Hand Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Fakin","sequence":"additional","affiliation":[{"name":"Division of Plastic and Hand Surgery University Hospital Zurich Zurich 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