{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:30:25Z","timestamp":1768275025548,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Following vascularized lymph node (VLN) transfer (VLNT), the VLN may be at a risk for sclerosis because of efferent lymphatic vessel obstruction. We developed a new technique to prevent VLN sclerosis via a prefabricated lympho\u2010venous (LV) shunt. This study compared the treatment outcomes of single VLNT with prefabricated LV shunt, conventional multiple VLNTs, and conventional single VLNT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 47 limbs of 45 patients that underwent VLNT for lower\u2010extremity lymphedema (LEL) in late clinical stage II\/III were divided into 3 groups: conventional single VLNT group (control; 21 limbs where 4 had primary LEL), multiple VLNTs group (13 limbs where 3 had primary LEL), and prefabricated LV shunt group (13 limbs where 4 had primary LEL). In the prefabricated LV shunt group, lymphaticovenular anastomosis between the efferent lymphatic vessel and small vein in the elevated VLN were performed simultaneously with VLNT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although venous thrombosis at the anastomosis site was observed in 1 case, it was salvaged by re\u2010anastomosis, and all VLNs survived. No other complications were observed. The LEL index significantly improved in the prefabricated LV shunt group compared with that in the control group (28.0\u2009\u00b1\u20091.7 vs 20.9\u2009\u00b1\u20091.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). In the prefabricated LV shunt group, all VLNs survived functionally, and the average size of the transferred lymph nodes was significantly larger than that of the control group (5.7\u2009\u00b1\u20090.1 vs 4.3\u2009\u00b1\u20090.2 mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prefabricated LV shunt may improve the efficacy of VLNT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30234","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:56:58Z","timestamp":1504717018000},"page":"270-277","source":"Crossref","is-referenced-by-count":16,"title":["Improvement of the efficacy of vascularized lymph node transfer for lower\u2010extremity lymphedema via a prefabricated lympho\u2010venous shunt through lymphaticovenular anastomosis between the efferent lymphatic vessel and small vein in the elevated vascularized lymph node"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-6602","authenticated-orcid":false,"given":"Shinsuke","family":"Akita","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-3565","authenticated-orcid":false,"given":"Hideki","family":"Tokumoto","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Chiba Cancer Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaro","family":"Sasahara","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motone","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Kochi Medical School Hospital Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Mitsukawa","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, and Aesthetic Surgery Chiba University Graduate School 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