{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:54:50Z","timestamp":1768913690408,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Itoe Okamoto Scholarship Grant"},{"name":"Hiroto Yoshioka Memorial fund for Medical Research"},{"name":"Terumo Foundation for Life Sciences and Arts General R&D subsidies"},{"name":"JSPS KAKENHI","award":["JP16K11382"],"award-info":[{"award-number":["JP16K11382"]}]},{"name":"Formation of Innovation Center for Fusion of Advanced Technologies in the Special Coordination Funds for Promoting Science and Technology \u201cCell Sheet Tissue Engineering Center (CSTEC)\u201d"},{"name":"The Global COE program, Multidisciplinary Education and Research Center for Regenerative Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study investigated the potential of collagen\u2010coated polyglycolic acid (PGA) tube with interpositional jump graft (IPJG) in rat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 16 Lewis rats were used in this study. Facial nerve paralysis was created by ligating facial nerve trunk with a ligature clip. The rats were divided into 3 groups. Nerve conduit group (<jats:italic>n<\/jats:italic>\u2009=\u20096) were treated by IPJG with collagen\u2010coated PGA tubes between the facial nerve trunks and the hypoglossal nerves. Autograft group (<jats:italic>n<\/jats:italic>\u2009=\u20096) were treated by IPJG with the greater auricular nerves. As the control group (<jats:italic>n<\/jats:italic>\u2009=\u20094), non\u2010treated\u2010model rats with facial nerve paralysis were used. The number of myelinated fibers, fiber diameter, axon diameter, myelin thickness, and g\u2010ratio, were analyzed histologically at 13 weeks after surgery. Compound muscle action potential (CMAP) and retrograde tracing were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Although the number of myelinated fibers in autograft group (1957\u2009\u00b1\u2009775) had significantly higher than that of nerve conduit group (90\u2009\u00b1\u200941, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), the nerve conduit group showed the regeneration of myelinated nerve axons. CMAP amplitude values of the autograft (4706\u2009\u00b1\u20091154 \u00b5V) and the nerve conduit groups (4119\u2009\u00b1\u20091397 \u00b5V) were significantly higher than that of the control group (915\u2009\u00b1\u2009789 \u00b5V, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Retrograde tracing confirmed the double innervation of mimetic muscles by the facial and hypoglossal nucleus in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed histologically and physiologically the superior effectiveness of performing IPJG with a collagen\u2010coated PGA conduit in a rat model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30291","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T07:56:40Z","timestamp":1515571000000},"page":"70-80","source":"Crossref","is-referenced-by-count":16,"title":["A collagen\u2010coated PGA conduit for interpositional\u2010jump graft with end\u2010to\u2010side neurorrhaphy for treating facial nerve paralysis in rat"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-380X","authenticated-orcid":false,"given":"Yosuke","family":"Niimi","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo 162\u20108666 Japan"},{"name":"Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-1169","authenticated-orcid":false,"given":"Hajime","family":"Matsumine","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo 162\u20108666 Japan"},{"name":"Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Physiology I (Neurophysiology) Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo, 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osaki","family":"Hironobu","sequence":"additional","affiliation":[{"name":"Department of Physiology I (Neurophysiology) Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo, 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"The Institute of Medical Science The University of Tokyo 4\u20106\u20101 Shirokanedai, Minato\u2010ku Tokyo, 108\u20108639 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Physiology I (Neurophysiology) Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo, 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yamato","sequence":"additional","affiliation":[{"name":"Institute of Advanced Biomedical Engineering and Science Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tokyo Women's Medical University 8\u20101 Kawada\u2010cho, Shinjuku\u2010ku Tokyo 162\u20108666 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.5.787"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000260232.43019.a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/JNS-07\/10\/0821"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.04.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp041120"},{"key":"e_1_2_7_7_1","first-page":"258","article-title":"Incidence and prognosis of Bell's palsy in the population of Rochester, Minnesota","volume":"46","author":"Hauser W. 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