{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:42:06Z","timestamp":1780638126567,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate outcome and safety of free flaps to the upper extremity by pooled, summarized rates, compared with the existing pooled results of the lower extremity from literature, and to improve the level of evidence in a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search of PubMed and Embase was conducted addressing publications between January 2000 and April 2018. Publications were selected by inclusion\/exclusion criteria on safety and outcome. Postoperative complications were statistically analyzed: flap loss, vessel thrombosis; recipient\u2010site infection, hematoma, seroma, wound dehiscence, dysesthesia; donor\u2010site morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and seventy\u2010nine patients with 283 free flaps from 23 publications were extracted and eligible for this meta\u2010analysis. The predominant donor site was the lower extremity (56%), with the anterolateral thigh flap as the major workhorse (30%). The summarized rate of total and partial flap loss was 6.0% (95% CI\u2009= 3.0\u20139.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 1.0000) and 8.0% (95% CI\u2009= 6.0\u201313.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9973), respectively. The rate of arterial and venous thrombosis was 5.0% (95% CI\u2009= 3.0\u20139.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9999) and 8.0% (95% CI\u2009= 9.0\u201337.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9804), respectively. Complication rates of recipient site were: early infection with 7.0% (95% CI\u2009= 4.0\u201311.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9788), hematoma with 6.0% (95% CI\u2009= 3.0\u20138.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 1.0000), seroma with 6.0% (95% CI\u2009= 4.0\u201310.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9948), dehiscence with 7.0% (95% CI\u2009= 4.0\u201311.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9988), and dysesthesia with 6% (95% CI\u2009= 4.0\u201310.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.9988). The rate of donor\u2010site morbidity was 14% (95% CI\u2009= 8.0\u201321.0%, <jats:italic>P<\/jats:italic><jats:sub><jats:italic>Q<\/jats:italic><\/jats:sub> = 0.0895).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Soft tissue free flaps to the upper extremity have comparable success rates, but higher perioperative complication rates (e.g.<jats:italic>,<\/jats:italic> partial flap loss, infection, and wound dehiscence) compared to the pooled data of lower extremity reconstruction from existing meta\u2010analysis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30460","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T09:10:38Z","timestamp":1555665038000},"page":"463-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Soft tissue free flap for reconstruction of upper extremities: A meta\u2010analysis on outcome and safety"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-224X","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg  Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-2793","authenticated-orcid":false,"given":"Emre","family":"Gazyakan","sequence":"additional","affiliation":[{"name":"Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg  Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-5132","authenticated-orcid":false,"given":"Amir K.","family":"Bigdeli","sequence":"additional","affiliation":[{"name":"Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg  Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Will\u2010Marks","sequence":"additional","affiliation":[{"name":"Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg  Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kneser","sequence":"additional","affiliation":[{"name":"Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg  Ludwigshafen 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