{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:46:35Z","timestamp":1780555595921,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Background<\/jats:title><jats:sec><jats:label\/><jats:p>Restoration of elbow flexion is the priority in traumatic brachial plexus injuries. Surgical approaches commonly include nerve transfers and nerve grafting. Our objective was to evaluate the safety and efficacy profile of nerve transfers versus grafting for traumatic nonobstetric brachial plexus injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic literature review was performed according to the PRISMA guidelines. A random\u2010effects model meta\u2010analysis was conducted, and the I\u2010square was used to assess heterogeneity. The Medical Research Scale (MRC) score was used to assess the efficacy of the procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies comprising 490 patients overall were identified. In the pooled analysis, functional recovery of elbow flexion defined as MRC \u2265 M3, was superior in the transfer (<jats:italic>N<\/jats:italic> = 272\/350, 77.7%) compared to the graft group (<jats:italic>N<\/jats:italic> = 99\/140, 70.7%); however statistical significance was not reached (OR: 1.95; 95%CI: 0.79\u20134.83; I<jats:sup>2<\/jats:sup>: 58.8%). However, the odds for successful restoration of elbow flexion (MRC\u2265M3) were significantly higher when the ulnar (OR:12.20; 95%CI:3.05\u201348.80; I<jats:sup>2<\/jats:sup>:0%) or pectoral nerves (OR: 9.69; 95% CI: 1.83\u201351.25; I<jats:sup>2<\/jats:sup>: 0%) were used as healthy donors for the transfer compared to the graft procedures. Results between the two groups were similar when the intercostal, spinal accessory, thoracodorsal, contralateral C7 and phrenic nerves were used as donors for the transfer procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ulnar or pectoral nerve transfer to musculocutaneous is associated with statistically significant superior rates of elbow flexion recovery as compared to graft. No differences were identified in the pooled analysis or the subgroups of other donors used in nerve transfers. Future randomized studies or prospective cohorts are needed to validate our results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30510","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T05:50:03Z","timestamp":1567662603000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Functional restoration of elbow flexion in nonobstetric brachial plexus injuries: A meta\u2010analysis of nerve transfers versus grafts"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8715-6651","authenticated-orcid":false,"given":"Pavlos","family":"Texakalidis","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, School of Medicine Emory University Hospital  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Hardcastle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine Emory University Hospital  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3300-6367","authenticated-orcid":false,"given":"Muhibullah S.","family":"Tora","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine Emory University Hospital  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Boulis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine Emory University Hospital  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.JNS132823"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"51","article-title":"Paralysis of the brachial plexus caused by supraclavicular injuries in the adult. 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