{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:01:40Z","timestamp":1791979300025,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral nerve damage resulting in pain, loss of sensation, or motor function may necessitate a reconstruction with a bridging material. The RANGER\u00ae Registry was designed to evaluate outcomes following nerve repair with processed nerve allograft (Avance\u00ae Nerve Graft; Axogen; Alachua, FL). Here we report on the results from the largest peripheral nerve registry to\u2010date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter IRB\u2010approved registry study collected data from patients repaired with processed nerve allograft (PNA). Sites followed their own standard of care for patient treatment and follow\u2010up. Data were assessed for meaningful recovery, defined as \u2265S3\/M3 to remain consistent with previously published results, and comparisons were made to reference literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 385 subjects and 624 nerve repairs. Overall, 82% meaningful recovery (MR) was achieved across sensory, mixed, and motor nerve repairs up to gaps of 70\u2009mm. No related adverse events were reported. There were no significant differences in MR across the nerve type, age, time\u2010to\u2010repair, and smoking status subgroups in the upper extremity (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Significant differences were noted by the mechanism of injury subgroups between complex injures (74%) as compared to lacerations (85%) or neuroma resections (94%) (<jats:italic>p<\/jats:italic> = .03) and by gap length between the &lt;15\u2009mm and 50\u201370\u2009mm gap subgroups, 91 and 69% MR, respectively (<jats:italic>p<\/jats:italic> = .01). Results were comparable to historical literature for nerve autograft and exceed that of conduit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings provide clinical evidence to support the continued use of PNA up to 70\u2009mm in sensory, mixed and motor nerve repair throughout the body and across a broad patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30574","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T13:37:03Z","timestamp":1582724223000},"page":"527-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Peripheral nerve repair throughout the body with processed nerve allografts: Results from a large multicenter study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-6526","authenticated-orcid":false,"given":"Bauback","family":"Safa","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The Buncke Clinic  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Jain","sequence":"additional","affiliation":[{"name":"Plastics and Reconstructive Surgery The Ohio State University Wexner Medical Center  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir J.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation Vanderbilt University Medical Center  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, Indiana Hand to Shoulder Center  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Niacaris","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery John Peter Smith Hospital  Fort Worth Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Nydick","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, Florida Orthopaedic Institute  Temple Terrace Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fraser J.","family":"Leversedge","sequence":"additional","affiliation":[{"name":"Divisions of Orthopaedic Surgery and Plastic Surgery, Department of Orthopaedic Surgery Duke University  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Megee","sequence":"additional","affiliation":[{"name":"Plastic, Reconstructive &amp; Hand Surgery University of Cincinnati  Cincinnati 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Plastic Surgery University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.","family":"Kao","sequence":"additional","affiliation":[{"name":"Plastics and Reconstructive Surgery The Ohio State University Wexner Medical Center  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"El\u2010Sheikh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic Reconstructive Surgery North York General Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata V.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Multidisciplinary Specialists  Rutherford New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie T.","family":"Shores","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery, School of 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