{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:10:59Z","timestamp":1791231059356,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T00:00:00Z","timestamp":1594425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary lymphedema is an anomaly of the regional lymphatic system with long symptom duration or severe lymphatic obstruction. Few microsurgical treatments for primary lymphedema have been reported. This aim of this study was to investigate the outcomes of microsurgical treatments in pediatric primary lymphedema patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2013 and 2017, pediatric primary lymphedema patients who underwent either lymphovenous anastomosis (LVA) or vascularized lymph node transfer (VLNT) were retrospectively reviewed. Cheng's Lymphedema Grading, Taiwan Lymphoscintigraphy Staging and indocyanine green lymphography were used to select the procedures. No compression garments were used postoperatively. Outcome measurements included circumferential difference, episodes of cellulitis, and Lymphedema\u2010specific Quality of life questionnaire (LYMQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients with mean age of 9.2\u2009years (range, 2\u201319\u2009years) with 11 lower and two upper lymphedematous limbs underwent 11 VLNT and two LVA. All VLNT flaps survived. At a mean 38.4\u2010months (range, 16\u201363 months) of follow\u2010up, the mean circumferential difference in nine unilateral lymphedematous limbs was improved by 6.7\u2009\u00b1\u20099.9% (<jats:italic>p<\/jats:italic>= .066). Two patients with bilateral lower limb lymphedema had mean limb circumference improvements of 1.3 and 6.5 cm, respectively. In nine limbs with cellulitis preoperatively, episodes of cellulitis decreased by 2.67 times\/year (<jats:italic>p<\/jats:italic>= .007). At a mean 22.3\u2010months of follow\u2010up (range, 13\u201324 months), the LYMQoL overall score in 6 patients older than 7\u2009years was improved by 3.2\u2009\u00b1\u20091.1 points (<jats:italic>p<\/jats:italic>= .007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymphedema microsurgery significantly improved the episodes of cellulitis and quality of life without utilizing compression garments in pediatric primary lymphedema patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30622","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T21:34:08Z","timestamp":1594503248000},"page":"766-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Lymphedema microsurgery improved outcomes of pediatric primary extremity lymphedema"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-2959","authenticated-orcid":false,"given":"Ming\u2010Huei","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital, College of Medicine, Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany Ting\u2010Fong","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital, College of Medicine, Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005870"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24170"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2011.0020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4700-3"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"8","article-title":"Quality of life following liposuction and conservative treatment of arm lymphedema","volume":"39","author":"Brorson H.","year":"2006","journal-title":"Lymphology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a4d626"},{"issue":"1","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jso.25514","article-title":"Intra\u2010abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis","volume":"121","author":"Chen C.","year":"2019","journal-title":"Journal of Surgical Oncology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31828bd3b3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.04.017"},{"issue":"12","key":"e_1_2_8_11_1","first-page":"e2056","article-title":"Outcomes of vascularized lymph node transfer and lymphovenous anastomosis for treatment of primary lymphedema","volume":"6","author":"Cheng M. H.","year":"2018","journal-title":"Plastic and Reconstructive Surgery"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002917"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13565"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002322"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920030109"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12282"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3518-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000383"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.01.007"},{"issue":"1","key":"e_1_2_8_21_1","first-page":"1","article-title":"A quality of life measure for limb lymphoedema (LYMQOL)","volume":"5","author":"Keeley V.","year":"2010","journal-title":"Journal of Lymphoedema"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-012-1565-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2012.05.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31819e6529"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2010.00030.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1413.010"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1381957"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4276-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24350"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000099"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000763"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00727-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1413.014"},{"issue":"2","key":"e_1_2_8_34_1","first-page":"167","article-title":"Turner's syndrome. Relationship between the karyotypes and malformations and associated diseases in 23 patients","volume":"47","author":"Ruibal Francisco J. L.","year":"1997","journal-title":"Anales Espa\u00f1oles de Pediatr\u00eda"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25237"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198503000-00020"},{"issue":"2","key":"e_1_2_8_37_1","first-page":"206","article-title":"Primary lymphedema in children and adolescents: A follow\u2010up study and review","volume":"76","author":"Smeltzer D. M.","year":"1985","journal-title":"Pediatrics"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61988-5"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.04.005"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004424"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.10.023"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049940"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmicr.30622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.30622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/micr.30622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.30622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:59:38Z","timestamp":1696391978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.30622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,11]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/micr.30622"],"URL":"https:\/\/doi.org\/10.1002\/micr.30622","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,11]]},"assertion":[{"value":"2019-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}