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To overcome these obstacles, we present a case of T4a gum cancer patient (41\u2010year\u2010old) who received holistic reconstruction of the mandible defect via an osteo\u2010peroneal\u2010artery\u2010perforator combined flap for defect coverage and cross\u2010mental nerve graft for lower lip and chin sensation at the primary stage, followed by ipsilateral facial nerve (lower trunk) innervated gracilis functioning free muscle transplantation for facial reanimation and correction of the sunken face 3\u2009years later. After 4.5\u2009years of follow\u2010up, the patient was satisfied with his appearance, and obtained a spontaneous and symmetrical smile without sensory deficit. This experience showed a possible solution to the reconstruction for complicated head and neck cancer patients.<\/jats:p>","DOI":"10.1002\/micr.30684","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T12:17:52Z","timestamp":1605269872000},"page":"361-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Holistic reconstruction of mandible defect, lower lip and chin sensation, and smile reanimation in an advanced gum cancer patient: A case report"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-7174","authenticated-orcid":false,"given":"Lisa Wen\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University  Taoyuan 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