{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:48:37Z","timestamp":1790884117342,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rat sciatic nerve injury (PNR) is the most utilized model in studies on peripheral nerve regeneration. However, large animal models are increasingly favored based on the assumption that nerve regeneration in rodents achieves more favorable outcomes than in humans. The purpose of this meta\u2010analysis was to investigate which rat PNR models are more stringent and should be used before utilizing large animal experimentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PRISMA\u2010guided meta\u2010analysis of the English literature regarding functional outcomes in rat peripheral nerve injury models was conducted. Outcomes of five basic scenarios: (1) transected nerve\/negative control, (2) transection with primary microsurgical repair, (3) isogenic\/autologous grafts, (4) acellular\u2010allogenic grafts, and (5) limb transplantation were compared to sciatic nerves without any intervention\/positive control. Outcomes were compared using Sciatic Functional Index (SFI). Log\u2010based projections were generated and evaluated using mean squared error (MSE), one\u2010way\u2010ANOVA, and Tukey\u2010HSD post\u2010hoc analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 167 articles met the inclusion criteria. The earliest manifestations of motor recovery were encountered in the transection and primary repair group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;.0005). There was a significant difference in recovery time and degree of recovery between all surgical models (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;.0005). At 24\u2009weeks, the SFI in hindlimb transplantation group was significantly worse than all other groups (\u221274.07\u2009\u00b1\u20092.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;.0005). Autografts smaller than 10\u2009mm recovered sooner than autografts longer than 10\u2009mm (\n                      <jats:italic>p<\/jats:italic>\n                      = .021) and autografts recovered faster than allografts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis does not support the belief that neuro\u2010regeneration is exceptional in transection models. These models remain adequate to provide translatable information and should initially be used in investigational studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/micr.30713","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T02:04:29Z","timestamp":1611885869000},"page":"286-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A\n                    <scp>meta\u2010analysis<\/scp>\n                    of functional outcomes in rat sciatic nerve injury models"],"prefix":"10.1002","volume":"41","author":[{"given":"Anthony","family":"DeLeonibus","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahe","family":"Fahradyan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rampazzo","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-6353","authenticated-orcid":false,"given":"Bahar","family":"Bassiri Gharb","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.056"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235063"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.01.014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000306107.70421.a4"},{"key":"e_1_2_8_6_1","first-page":"31","article-title":"The rate of regeneration of nerve","volume":"19","author":"Gutmann E. 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