{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:18:06Z","timestamp":1774340286799,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The profunda artery perforator (PAP) flap has been reported in several types of reconstructions. This report aims to evaluate the usefulness and the clinical outcome of patients who underwent the PAP free flap for lower limb reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between February 2018 and February 2020, nine patients with injury at lower third of the leg, foot dorsum or foot plant (eight acute injuries and one chronic ulcer) were selected. Mean wound size was 12.5\u2009\u00d7\u20096.3\u00a0cm (9\u2009\u00d7\u20095\u201314.5\u2009\u00d7\u20096.5). Inclusion criteria consisted in patient's request to hide the donor site scar and the absence of previous traumas or surgery in the donor site. Patients considered unable to bear prolonged surgery were excluded. Patients underwent preoperative CT angiography and peri\u2010operative Doopler, for perforator selection. All flaps were designed with pinch test, in elliptical shape. Microvascular anastomosis was performed to the tibialis anterior\/posterior or medial plantar vessels. Outcomes were evaluated in terms of wound coverage success and patient's quality of life through Lower Extremity Functional Scale (LEFS) questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean size of the harvested skin paddle was 13.5\u2009\u00d7\u20097.4\u00a0cm (9\u2009\u00d7\u20096\u201315\u2009\u00d7\u20098) and mean pedicle length was 8.5\u00a0cm. Mean flap harvest time was 43.5\u00a0min (35\u201355). Flap survival rate was 100%, with one re\u2010exploration with minimal partial flap loss. Mean follow\u2010up was 13.5\u00a0months . Reconstructive results were successful in wound coverage and function. All patients reported satisfaction with their result by LEFS questionnaire (score:64.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With proper patient selection, there was 100% flap survival rate with no major complication. According to our data, the PAP free flap could be a valuable option for lower extremity reconstruction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30745","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T16:07:16Z","timestamp":1619107636000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The profunda artery perforator free flap for lower extremity reconstruction"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-2676","authenticated-orcid":false,"given":"Pedro","family":"Ciudad","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery Arzobispo Loayza National Hospital  Lima Peru"},{"name":"Department of Research, Teaching and Biotechnology Experimental Surgery Unit. The Child Health's Institute (Bre\u00f1a)  Lima Peru"},{"name":"Division of Plastic Surgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juste","family":"Kaciulyte","sequence":"additional","affiliation":[{"name":"Department of Surgery \"P.Valdoni\", Unit of Plastic and Reconstructive Surgery Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-3614","authenticated-orcid":false,"given":"Federico Lo","family":"Torto","sequence":"additional","affiliation":[{"name":"Department of Surgery \"P.Valdoni\", Unit of Plastic and Reconstructive Surgery Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ines","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery Arzobispo Loayza National Hospital  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atenas","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery Arzobispo Loayza National Hospital  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Maruccia","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery China Medical University Hospital  Taichung Taiwan"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation University of Bari Aldo Moro  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Zulueta","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Burn Surgery Arzobispo Loayza National Hospital  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Trignano","sequence":"additional","affiliation":[{"name":"Department of Surgery \"P.Valdoni\", Unit of Plastic and Reconstructive Surgery Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6418-2873","authenticated-orcid":false,"given":"Alberto","family":"Bolletta","sequence":"additional","affiliation":[{"name":"Plastic Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000244848.10434.5f"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182363d9f"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200106000-00013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.09.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30681"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1695051"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1348065"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007026"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.11.019"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30413"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GOX.0000502972.55792.37"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22459"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198503000-00008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003944"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003553"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.21980"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2020.1773478"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30485"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2018.05.046"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24294"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20551"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(89)90075-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200106000-00019"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003881"},{"issue":"5","key":"e_1_2_10_26_1","first-page":"590","article-title":"Repair of limb wounds with free profunda artery perforator flap in posteromedial femoral region","volume":"33","author":"Liu Y.","year":"2019","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"e_1_2_10_27_1","article-title":"Patient reported outcomes (PROs) \u2010 a tool for strengthening patient involvement and measuring outcome in Orthopaedic outpatient rehabilitation","author":"M\u00fcller M.","year":"2020","journal-title":"Zeitschrift f\u00fcr Orthop\u00e4die und Unfallchirurgie"},{"issue":"1","key":"e_1_2_10_28_1","first-page":"72","article-title":"Indocyanine green lymphography findings in limb lymphedema","volume":"32","author":"Narushima M.","year":"2016","journal-title":"Journal of Reconstructive Microsurgery"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688712"},{"issue":"6","key":"e_1_2_10_30_1","first-page":"381","article-title":"The anatomic basis of the profunda femoris artery perforator flap: A new option for autologous breast reconstruction\u2010 \u2010a cadaveric and computer tomography angiogram study","volume":"28","author":"Saad A.","year":"2012","journal-title":"Journal of Reconstructive Microsurgery"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31819f2c6a"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000587"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30074"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(84)90002-X"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(87)90185-8"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001837"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197909000-00002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.09.022"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001880"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.30745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/micr.30745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.30745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:42:33Z","timestamp":1693208553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.30745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/micr.30745"],"URL":"https:\/\/doi.org\/10.1002\/micr.30745","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]},"assertion":[{"value":"2020-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}