{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:29:48Z","timestamp":1780385388745,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As a promising treatment for lymphedema, vascularized lymph node transfer (VLNT) is associated with a risk of iatrogenic lymphedema. Intra\u2010abdominal vascularized lymph node flap has been increasingly applied to minimize complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Web of Sciences, and Cochrane databases were searched systematically. Clinical articles describing the application of intra\u2010abdominal flaps to treat lymphedema were included. Study characteristics, patient demographics, and operative details were recorded. Primary outcomes were recorded as circumference\/volume reduction, episodes of cellulitis reduction and lymph flow assessment. Secondary outcomes were recorded as donor\u2010site complication and recipient\u2010site complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one studies met the inclusion criteria with 594 patients in total. Donor\u2010sites of flaps were omental\/gastroepiploic, jejunal, ileocecal, and appendicular. The mean reduction rate ranged from 0.38% to 70.8%. Significant reduction in infectious episodes was reported in 10 studies. The pooled donor\u2010site complication rate was 1.4% (95% CI, 0%\u20134.1%;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200940%). The pooled recipient\u2010site complication rate was 3.2% (95% CI, 1.4%\u20135.5%;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200939%). The most common donor\u2010site complication was minor ileus requiring prolonged nasogastric tube replacement. No donor site lymph disfunction occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intra\u2010abdominal VLNT is an effective technique for patients with lymphedema with no obvious impairment to donor\u2010site lymph function, as long as the operation is properly performed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30812","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T11:33:30Z","timestamp":1632569610000},"page":"802-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intra\u2010abdominal vascularized lymph node transfer for treatment of lymphedema: A systematic literature review and meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7908","authenticated-orcid":false,"given":"Yunzhu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2017.08.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24969"},{"key":"e_1_2_8_4_1","volume-title":"Critical appraisal checklist","author":"ASPS","year":"2015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000201258.10304.16"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.08.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2006.4404"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31828bd3b3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24730"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25360"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30186"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2020.01.14"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30168"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30134"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24349"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22450"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.08.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30641"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25581"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002505"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197412000-00009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196710000-00006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03140130031006"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004772"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"e2436","DOI":"10.1097\/GOX.0000000000002436","article-title":"Flow\u2010through omental flap for vascularized lymph node transfer: A novel surgical approach for delayed lymphatic reconstruction","volume":"7","author":"Johnson A. 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