{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:50:20Z","timestamp":1790639420021,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with soft tissue tumors of extremities are at risk to develop secondary lymphedema after tumor resection caused by disruption of lymphatic vessels and sclerosis. Subsequently, this study aimed to evaluate the beneficial effects of lymphaticovenous anastomoses (LVAs) after soft tissue tumor resection of the thigh in a prophylactic approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study, we compared eight patients with a median age of 68.5\u2009years (49\u201380) who received LVAs in combination with tumor resection for treatment of soft tissue tumors of the thigh region with a prior cohort of 20 patients with a median age of 63.0\u2009years (23\u201384) who received soft tissue sarcoma resection of the thigh region. All patients of LVA cohort received 1\u20132 LVAs (mean 1.25\u00a0\u00b1\u20090.49) at the dorsum of the foot and three patients at the SEKI\u2010point (mean 0.375\u2009\u00b1\u20090.51). Mean maximum tumor diameter of LVA group was 19.5\u2009\u00b1\u20095.2\u00a0cm and 12.3\u2009\u00b1\u20096.6\u00a0cm of control group. All patients receiving LVA were assessed for development of lymphedema via bilateral measurements of circumference and assessment of lymphedema quality of life index (LyQLI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One of the eight patients who received LVAs showed moderate impairment in the LyQLI at a follow\u2010up of 12\u2009months while 45% of the control cohort complained about symptoms of secondary lymphedema at a median follow\u2010up of 22\u2009months (<jats:italic>p<\/jats:italic>\u2010values LyQLI: <jats:italic>p<\/jats:italic>\u00a0=\u2009.018 [physical domain]; <jats:italic>p<\/jats:italic>\u00a0=\u2009.018 [psychosocial domain]; <jats:italic>p<\/jats:italic>\u00a0=\u2009.020 [practical domain]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LVAs performed in combination with tumor resection of thigh soft tissue tumors reduce negative consequences of lymph stasis and prevent development of secondary lymphedema.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30850","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T07:18:05Z","timestamp":1640330285000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prophylactic lymphaticovenous anastomoses for resection of soft tissue tumors of the thigh to prevent secondary lymphedema\u2013a retrospective comparative cohort analysis"],"prefix":"10.1002","volume":"42","author":[{"given":"Johannes Maximilian","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-2982","authenticated-orcid":false,"given":"Mehran","family":"Dadras","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Ufton","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julika","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wallner","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sogorski","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxi","family":"von Glinski","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Pio","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Asan Medical Center, University of Ulsan  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Lehnhardt","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-6956","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Behr","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BG University Hospital Bergmannsheil, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22254"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"71","article-title":"LyMPHA and the prevention of lymphatic injuries: A rationale for early microsurgical intervention","volume":"30","author":"Campisi C. 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