{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:13:36Z","timestamp":1775902416943,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In free flaps, 5%\u201310% of complications are related to failure of sutured vascular anastomoses. Adhesive\u2010based microvascular anastomoses are potential alternatives but are associated with failure rates of 70% in research studies. VIVO is a new adhesive with slow biodegradation within 6\u00a0months that has shown a 100% patency rate in research studies over 2\u00a0h observation time but long\u2010term patency has not been evaluated. The authors hypothesize that VIVO will enable a reliable microvascular procedure comparable to sutured anastomoses over a 28\u2010day period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The right common carotid artery of 60 male Sprague Dawley rats, ~450\u2009g, were used for microvascular end\u2010to\u2010end anastomosis. VIVO was applied with reduced sutures with a temporary catheter in one group and in the other with a custom\u2010shaped memory stent. Anastomoses with eight interrupted sutures served as control. All groups were <jats:italic>n<\/jats:italic>\u00a0=\u00a020. Anastomosis time and bleeding were recorded for each procedure. Doppler flowmetry was performed 20\u2009min, 1, 10, and 28\u2009days postoperatively. Postmortem toluidine staining was used for semi\u2010quantitative analysis of stenosis, thrombosis, necrosis, and aneurysm formation by histologic evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No occlusion was detected 20\u2009min and 1\u00a0day postoperative, and after 28 days of observation in all anastomoses. The anastomosis time of the VIVO with catheter group was about 32% significantly faster than the VIVO with stent group. In the VIVO group with stent, the bleeding time was ~80% shorter than in the control group with 2.1\u2009\u00b1\u20090.3 and VIVO with catheter 2.0\u2009\u00b1\u20090.5 (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.001 each). Minor and nonsignificant stent\u2010associated thrombus formation and stent\u2010typical intraluminal stenosis were detected exclusively in the VIVO with stent group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of a rat study, the use of VIVO in anastomosis showed promising results. VIVO with catheter was found to be advantageous.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.30926","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T07:57:04Z","timestamp":1654588624000},"page":"480-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of the long\u2010term results of vascular anastomosis using polyurethane adhesive and shape\u2010memory stent in the rat carotid artery model"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-6065","authenticated-orcid":false,"given":"Marius","family":"Heitzer","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ooms","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Sophie","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Tolba","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science and Experimental Surgery of RWTH\u2010Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Jockenhoevel","sequence":"additional","affiliation":[{"name":"Department of Biohybrid and Medical Textiles (BioTex), AME\u2010Helmholtz Institute for Biomedical Engineering RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benita","family":"Hermanns\u2010Sachweh","sequence":"additional","affiliation":[{"name":"Implant Pathology ZBMT, Campus Melaten  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"H\u00f6lzle","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Modabber","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Hospital of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1605587"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.11.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000245007.33054.98"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20494"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20554"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920040106"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000475774.37267.3f"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2000.00143.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481818"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.07.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2752(1998)18:5<306::aid-micr2>3.0.co;2-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92998-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2021.151782"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10004-7"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i11.776"},{"issue":"4","key":"e_1_2_10_21_1","first-page":"199","article-title":"Microvascular anastomosis using histoacryl glue and an intravascular soluble stent","volume":"29","author":"Lemaire D.","year":"2000","journal-title":"The Journal of Otolaryngology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800482"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004725"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/BMT.2011.006"},{"issue":"5","key":"e_1_2_10_25_1","first-page":"363","article-title":"Histoacryl glue in microvascular surgery","volume":"20","author":"Middleton W. G.","year":"1991","journal-title":"The Journal of Otolaryngology"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20984"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.04.005"},{"issue":"2","key":"e_1_2_10_28_1","first-page":"227","article-title":"Microvascular anastomosis using a blood product sealant\u2010adhesive","volume":"144","author":"Pearl R. M.","year":"1977","journal-title":"Surgery, Gynecology & Obstetrics"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22381"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2007.8.3.269"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001808"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1597823"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181520"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1058088"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33409"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9610(01)00771-1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350617720993"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2478\/pjs-2014-0030"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30082"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.02.017"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.30926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/micr.30926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.30926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:25:53Z","timestamp":1692836753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.30926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/micr.30926"],"URL":"https:\/\/doi.org\/10.1002\/micr.30926","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"value":"0738-1085","type":"print"},{"value":"1098-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]},"assertion":[{"value":"2021-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}