{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:07:34Z","timestamp":1787170054401,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The healthcare industry's efforts to immunize the global community against severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) have been unprecedented. Given the fast\u2010tracking of the novel vaccine, its short\u2010 and long\u2010term medical implications remain largely to\u2010be\u2010determined in most patient populations. This study aims to analyze 90\u2010day post\u2010operative outcomes in microsurgical patients, who have received or not received SARS\u2010CoV\u20102\u2010vaccination, using a continuously updated federated electronic medical record network (TriNetX Inc, Cambridge, MA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After screening 70 million de\u2010identified records, 16,799 microsurgery patients aged 18\u201399 meeting medical coding criteria were allocated into two cohorts. Cohort One received SARS\u2010CoV\u20102\u2010vaccination prior to undergoing microsurgery whereas Cohort Two did not. Two equally sized cohorts, totaling 818 patients were created after propensity score matching for characteristics including: age, race, ethnicity, smoking, hypertension, heart disease, diabetes, obesity, chronic obstructive pulmonary disease, and history of SARS\u2010CoV\u20102 exposure. Postoperative outcomes within 30\u2010, 60\u2010, and 90\u2010days of microsurgery were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients who were SARS\u2010CoV\u20102\u2010immunized experienced significantly lower (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) surgical site infections (Absolute Risk Reduction (ARR)[95%CI])\u00a0=\u00a0(3.79%\u20135.36% [0.84\u20138.54]) ICU admission (9.47%\u20139.82%[5.45\u201313.88]), generalized infections (7.68%\u20139.92%[3.15\u201314.64]), and hospitalizations (28.48%\u201332.57%[20.99\u201340.13]) within 30\u2010, 60\u2010, and 90\u2010days of microsurgery. Additionally, SARS\u2010CoV\u20102\u2010vaccinated patients also experienced significantly less flap failure (2.49%[0.97\u20134.02]) and death (2.46%[0.96\u20133.97]) within 30\u2010 and 60\u2010days post\u2010operatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our analysis examines the potential protective effect of SARS\u2010CoV\u20102\u2010vaccination in microsurgical patients. Limitations include the retrospective nature of this analysis and the inherent reliance on medical coding. Future prospective studies are warranted to better understand if in fact pre\u2010operative SARS\u2010CoV\u20102\u2010vaccination has the potential to protect against post\u2010operative microsurgery outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/micr.30940","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:44:57Z","timestamp":1657867497000},"page":"685-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The influence of\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 vaccination on post\u2010operative outcomes in microsurgery patients"],"prefix":"10.1002","volume":"42","author":[{"given":"Susan M.","family":"Taghioff","sequence":"first","affiliation":[{"name":"Division of Plastic &amp; Reconstructive Surgery University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Anne Arundel Medical Center Luminis Health 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