{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:37:19Z","timestamp":1788565039161,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Nerve conduits are either used to bridge nerve gaps of up to 3\u2009cm or to protect nerve coaptations. Biodegradable nerve conduits, which are currently commercially available, include\n                      <jats:bold>Chitosan<\/jats:bold>\n                      or\n                      <jats:bold>collagen<\/jats:bold>\n                      \u2010based ones. As histological aspects of their degradation are highly relevant for the progress of neuronal regeneration, the aim of this study was to report the histopathological signs of such nerve conduits, which were removed during revision surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Either\n                      <jats:bold>Chitosan<\/jats:bold>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) or\n                      <jats:bold>collagen<\/jats:bold>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) nerve conduits were implanted after neuroma resection and nerve grafting (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) or traumatic nerve lesion after cut (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) or crush injury (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) in two females and two men, aged between 17 and 57\u2009years. Revision surgery with removal of the nerve conduits was indicated due to persisting neuropathic pain and sensorimotor deficits, limited joint motion, or neurolysis with hardware removal at a median time of 17\u2009months (range: 5.5\u201348\u2009months). Histopathological analyses of all removed nerve conduits were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A scar neuroma was diagnosed in one out of four patients. Mechanical complication occurred in one patient after nerve conduit implantation bridged over finger joints. Intraoperatively no or only initial signs of degradation of the nerve conduits were observed.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Chitosan<\/jats:bold>\n                      conduits revealed largely unchanged shape and structure of chitosan, and coating of the conduit by a vascularized fibrous membrane. The latter contained deposits taken up by macrophages, most likely representing dissolved chitosan.\n                    <\/jats:p>\n                    <jats:p>\n                      Characteristic histopathologic features of the degradation of\n                      <jats:bold>collagen<\/jats:bold>\n                      conduits were a disintegration of the compact collagen into separate fine circular strands, No foreign body reaction was observed in all removed nerve conduits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Both\n                      <jats:bold>Chitosan<\/jats:bold>\n                      nerve conduits have not been degraded. The\n                      <jats:bold>collagen<\/jats:bold>\n                      nerve conduits showed a beginning degradation process. Furthermore, wrapping the repaired nerve with a nerve conduit did neither prevent adhesions nor improved nerve gliding. Therefore, biodegradation in time should be particularly addressed in further developments of nerve conduits.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/micr.31093","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T08:01:19Z","timestamp":1689926479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non degradation of chitosan and initial degradation of collagen nerve conduits used for protection of nerve coaptations"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-1856","authenticated-orcid":false,"given":"Susanne","family":"Rein","sequence":"first","affiliation":[{"name":"Department of Plastic and Handsurgery Burn Unit, Klinikum St. Georg gGmbH  Leipzig Germany"},{"name":"Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle (Saale) 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