{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:59:41Z","timestamp":1782946781462,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying at\u2010risk patients for complications remains challenging in patients with chronic lower extremity (LE) wounds receiving free tissue transfer (FTT) for limb salvage. The modified\u20105 frailty index (mFI\u20105) has been utilized to predict postoperative complications, yet it has not been studied in this population. The aim of this study was to determine the utility of the mFI\u20105 in predicting adverse postoperative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients \u226560\u2009years, who underwent LE FTT reconstruction at a single institution from 2011 to 2022, were retrospectively reviewed. Patient characteristics, mFI\u20105, and postoperative outcomes were collected. Cohorts were divided by an mFI\u20105 score of &lt;2 or \u22652.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 115 patients were identified, of which 71.3% (<jats:italic>n<\/jats:italic>\u2009=\u200982) were male, 64.3% (<jats:italic>n<\/jats:italic>\u2009=\u200974) had a mFI\u20105 score of \u22652, and 35.7% (<jats:italic>n<\/jats:italic>\u2009=\u200941) had a score &lt;2. The average age and body mass index were 67.8\u2009years and 28.7\u2009kg\/m<jats:sup>2<\/jats:sup>, respectively. The higher mFI\u20105 cohort had lower baseline albumin levels (3.0 vs. 4.0\u2009g\/dL, <jats:italic>p<\/jats:italic>\u2009=\u2009.015) and higher hemoglobin A1c levels (7.4 vs. 5.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The postoperative length of stay was longer in the higher mFI\u20105 cohort (18 vs. 13.4\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u2009.003). The overall flap success was 96.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009111), with no difference between cohorts (<jats:italic>p<\/jats:italic>\u2009=\u2009.129). Postoperative complications were comparable between cohorts (<jats:italic>p<\/jats:italic>\u2009=\u2009.294). At a mean follow\u2010up of 19.8\u2009months, eight patients (7.0%) underwent amputation, and 91.3% (<jats:italic>n<\/jats:italic>\u2009=\u2009105) were ambulatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High microsurgical success rates can be achieved in comorbid patients with high frailty indexes who undergo FTT for limb salvage. A multidisciplinary team approach may effectively mitigate negative outcomes in elderly, frail patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.31135","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T07:23:11Z","timestamp":1703143391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical utility of the modified frailty index in predicting adverse outcomes in patients undergoing lower extremity free flap reconstruction"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4551-7436","authenticated-orcid":false,"given":"Romina","family":"Deldar","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-8384","authenticated-orcid":false,"given":"Samuel S.","family":"Huffman","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-7964","authenticated-orcid":false,"given":"John D.","family":"Bovill","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian N.","family":"Truong","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb K.","family":"Haffner","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-5970","authenticated-orcid":false,"given":"Adaah A.","family":"Sayyed","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.3969"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2021.01.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1384664"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1675146"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/sap.0000000000002335"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012604"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S267349"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5253-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000262740.34106.1b"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.10.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1675145"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2022.2070175"},{"key":"e_1_2_8_14_1","volume-title":"American Society of Anesthesiologists Classification","author":"Doyle D. 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