{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:01:52Z","timestamp":1753869712302,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Soft\u2010tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin and account for only 1% of adult malignancies. They tend to occur most commonly in the lower extremities. Reconstruction after sarcoma resection can be challenging, especially when important structures are involved and recurrences occur. Additionally, more attention is now being paid to reconstructing the lymphatic system to prevent lymphatic complications. In this case report, we presented the management of recurrent medial thigh sarcoma that necessitated multiple challenging reconstructions to provide valuable insights for lectures on similar cases. A 50\u2010year\u2010old male patient was diagnosed with an undifferentiated pleomorphic cell sarcoma (UPS) of the anteromedial thigh. After preoperative radiotherapy, a mass of 23\u2009\u00d7\u200915\u2009cm was removed, and reconstruction with a pedicled deep inferior epigastric artery perforator (p\u2010DIEP) flap\u2010based lymphatic flow through (LyFT) was performed. Six months later, the patient developed the first local recurrence with the presence of a distant metastasis. Following the tumor resection, the medial part of the DIEP flap was de\u2010epithelized and buried in the defect for dead space obliteration. Another local recurrence arose 7\u2009months after the second surgery. Therefore, a major debulking surgery involving the femoral neurovascular bundle was performed. The femoral artery was reconstructed with a synthetic graft, and the femoral vein with the great saphenous vein harvested from the contralateral thigh. A composite myocutaneous neurotized anterolateral thigh (ALT) flap from the contralateral thigh was used to obliterate the defect and restore the loss of function of the quadriceps femoris. Two lymphaticovenular anastomoses (LVAs) were performed at the ankle to reduce the risk of lymphatic sequelae. This case report highlights the importance of integrating various techniques to create a tailored approach that effectively addresses complex surgical requirements to avoid limb amputation and maintain functionality.<\/jats:p>","DOI":"10.1002\/micr.31224","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T12:05:11Z","timestamp":1725278711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of a Complex, Recurrent Case of Medial Thigh Sarcoma With Pedicled Deep Inferior Epigastric Artery Perforator (<scp>DIEP<\/scp>) Lymphatic Flow\u2010Through (<scp>LyFT<\/scp>) Flap and Secondary Anterolateral Thigh (<scp>ALT<\/scp>) Free Flap With Innervated Vastus Lateralis Anastomosed to Synthetic Artery Graft: A Case Report"],"prefix":"10.1002","volume":"44","author":[{"given":"Federica","family":"Martini","sequence":"first","affiliation":[{"name":"Zentrum f\u00fcr Plastische Chirurgie Pyramid Clinic  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-6985","authenticated-orcid":false,"given":"Matteo","family":"Meroni","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Plastische Chirurgie Pyramid Clinic  Zurich Switzerland"},{"name":"Department of Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5289-9140","authenticated-orcid":false,"given":"Mario\u00a0F.","family":"Scaglioni","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Plastische Chirurgie Pyramid Clinic  Zurich Switzerland"},{"name":"Department of Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"},{"name":"Department of Hand and Plastic Surgery Luzerner Kantonsspital  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1055\/s-2007-1006677"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1002\/micr.31121"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/j.bjps.2024.01.055"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1097\/01.prs.0000297634.53915.e5"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1016\/j.bjps.2020.01.014"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1002\/micr.20859"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.3322\/caac.21605"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1097\/01.SAP.0000070433.06200.2C"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1097\/PRS.0000000000004697"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1097\/PRS.0000000000007636"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1002\/micr.30246"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1002\/jso.26228"},{"issue":"1","key":"e_1_2_7_14_1","first-page":"91","article-title":"Management of Lower Limb Soft Tissue Sarcomas With Major Neurovascular Involvement: Current and Future Perspectives","volume":"9","author":"Tamimi N.","year":"2021","journal-title":"EMJ"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1016\/j.bjps.2004.06.003"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1097\/PRS.0b013e3181cb67bd"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1200\/JCO.2017.75.3467"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.31224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T10:55:45Z","timestamp":1726656945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.31224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/micr.31224"],"URL":"https:\/\/doi.org\/10.1002\/micr.31224","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"type":"print","value":"0738-1085"},{"type":"electronic","value":"1098-2752"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31224"}}