{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:45:05Z","timestamp":1764434705532,"version":"3.46.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Targeted nipple areola complex (NAC) reinnervation (TNR) to restore nipple and chest sensation has been previously described in patients undergoing breast reconstruction and gender\u2010affirming mastectomy. A healthy 32\u2010year\u2010old male, with grade II gynecomastia with severe skin laxity and a BMI of 25\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , underwent bilateral mastectomy with free nipple grafting (FNG) for persistent gynecomastia and chest wall soft tissue laxity. The mastectomy weight was 242.5 (range: 242\u2013243) grams. Three lateral intercostal nerves (3rd, 4th and 5th) were preserved and directly coaptated to the new NAC on each side. Quantitative and patient\u2010reported sensory evaluation was conducted at 18\u2009months follow\u2010up, revealing a median monofilament detection threshold of 3.61 (range: 2.83\u20133.61) at the NAC and 2.83 (2.83\u20133.61) at the chest wall as well as pain from pressure at a median of 100.0\u2009kPa (range: 77.4\u2013122.5) at the NAC and 151.5\u2009kPa (range: 116.6\u2013183.3) at the chest. While the median two\u2010point discrimination was 3.0\u2009cm (range: 1.5\u20134.0) at the chest wall, two\u2010point discrimination could not be detected at the NAC. The patient was \u201cvery satisfied\u201d with nipple and chest sensation and did not report any nipple hypersensitivity, nipple\/chest pain, or phantom sensation\/pain. TNR was able to restore various quantitative and patient\u2010reported sensory functions at the NAC and chest with high patient satisfaction. This report provides the first quantitative sensory outcomes from TNR for restoration of sensation after mastectomy for the treatment of gynecomastia in a male patient.\n                  <\/jats:p>","DOI":"10.1002\/micr.70060","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T11:03:52Z","timestamp":1743678232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Nipple Areola Complex Reinnervation in Gynecomastia Mastectomy: A Case Report"],"prefix":"10.1002","volume":"45","author":[{"given":"Elizabeth E.","family":"Blears","sequence":"first","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery Tower Health Hospital System  West Reading Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Remy","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviu","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian L.","family":"Valerio","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-3437","authenticated-orcid":false,"given":"Lisa","family":"Gfrerer","sequence":"additional","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004559"},{"volume-title":"Plastic and Reconstructive Breast Surgery","year":"2010","author":"Bostwich J.","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.3352"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000912"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004420"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004251"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2022.06.034"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003388"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/trgh.2020.0070"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2022.02.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.4678"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.46782"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006192"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637\u2010199203000\u201000004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007\u20101226(74)90027\u20107"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005203"}],"container-title":["Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/micr.70060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T16:41:28Z","timestamp":1764434488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/micr.70060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/micr.70060"],"URL":"https:\/\/doi.org\/10.1002\/micr.70060","archive":["Portico"],"relation":{},"ISSN":["0738-1085","1098-2752"],"issn-type":[{"type":"print","value":"0738-1085"},{"type":"electronic","value":"1098-2752"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"assertion":[{"value":"2024-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70060"}}