{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:28:33Z","timestamp":1773174513390,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recurrent anal cancer (AC) often requires surgical intervention, especially when large perineal defects must be reconstructed. These cases are complicated by poor tissue vascularity and comorbid conditions such as peripheral arterial disease (PAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report the case of a 64\u2010year\u2010old male with PAD and recurrent AC, presenting with a large perineal defect following radical pelvic exenteration. Preoperative iliac artery stenting was performed to ensure adequate perfusion. Surgical reconstruction was conducted in two stages: first, a vertical rectus abdominis myocutaneous (VRAM) flap (7\u2009\u00d7\u200915\u2009cm) for pelvic floor coverage, followed by a free latissimus dorsi (LD) flap (17\u2009\u00d7\u200930\u2009cm) anastomosed to the superior gluteal vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative recovery was uneventful. Three vacuum\u2010assisted closures were performed, and the patient was discharged 6\u2009weeks postoperatively. At 6\u2010month follow\u2010up, the flap remained stable with no complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case underscores the importance of preoperative vascular optimization and a staged surgical strategy when addressing large, complex perineal defects. Multidisciplinary collaboration is critical for achieving optimal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/micr.70073","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T10:51:12Z","timestamp":1748947872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reconstruction of a Large Perineal Defect After Radical Oncological Pelvic Exenteration in a Patient With Anal Cancer: An Interdisciplinary Approach and Literature Review"],"prefix":"10.1002","volume":"45","author":[{"given":"Mohammadsadegh","family":"Sabagh","sequence":"first","affiliation":[{"name":"Department of General, Visceral, and Transplantation Surgery University of Heidelberg  Heidelberg Germany"},{"name":"Department of Hand, Plastic and Reconstructive Surgery, Burn Center BG Trauma Center Ludwigshafen  Ludwigshafen Germany"},{"name":"Department of Hand and Plastic Surgery University of Heidelberg  Heidelberg 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