{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T11:46:27Z","timestamp":1775994387253,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microsurgery"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The association between preoperative systemic inflammatory markers and postoperative free flap complications remains insufficiently defined, particularly in trauma\u2010related reconstructions. The aim of our study was to investigate the association between systemic inflammatory markers and postoperative complications of free flaps used in soft tissue reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study. The main independent variables were systemic inflammatory markers such as neutrophil, lymphocyte, monocyte, platelet, neutrophil\u2010lymphocyte ratio (NLR), platelet\u2010lymphocyte ratio (PLR), lymphocyte\u2010monocyte ratio (LMR), systemic inflammatory response index (SIRI), and systemic immune inflammatory index (SII). The relationship between complications and inflammatory markers was analyzed. Cut\u2010off values, sensitivity, and specificity of the associated markers were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study consisted of 55 patients, 40 (72.7%) were men and 15 (27.3%) were women. Their average age was 33.63\u2009years with a standard deviation of 15.34\u2009years. The cumulative complication rate was 40% (22 patients). In the group with complications, NLR, PLR, and SII values were significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values were 0.008, 0.002, and 0.002, respectively). Cut\u2010off values with the sensitivity and specificity were NLR &gt;\u20092.68 (63.6% sensitivity, 84.8% specificity), PLR\u2009&gt;\u2009148.64 (81.8% sensitivity, 57.5% specificity), SII\u2009&gt;\u2009656.91 (72.7% sensitivity, 78.7% specificity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The inflammatory indices NLR, PLR, SII were found to be associated with postoperative complications and demonstrated specific cut\u2010off values; however, these findings should be interpreted as associative rather than predictive.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/micr.70218","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:14:31Z","timestamp":1774534471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Systemic Inflammatory Markers With Complications in Free Flap Reconstruction: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8073-3471","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"Acar","sequence":"first","affiliation":[{"name":"Clinic of Orthopaedic and Traumatology Istanbul Education and Research Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethem Ayhan","family":"\u00dcnkar","sequence":"additional","affiliation":[{"name":"Clinic of Hand Surgery Baltaliman\u0131 Special Bone Diseases Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Ertem","sequence":"additional","affiliation":[{"name":"Clinic of Hand Surgery Malatya Education and Research Hospital  Malatya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"\u015eencan","sequence":"additional","affiliation":[{"name":"Clinic of Hand Surgery Baltaliman\u0131 Special Bone Diseases Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Orman","sequence":"additional","affiliation":[{"name":"Clinic of Hand Surgery Baltaliman\u0131 Special Bone Diseases Hospital  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.05.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1118053"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0033-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179553"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067688"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27196"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017431.2020.1846774"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2025.03.043"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.12.011"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-023-03018-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1218047"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-016-0904-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.04.019"},{"issue":"1","key":"e_1_2_12_16_1","first-page":"65","article-title":"Proximal Femoral Nail Causes Lower Systemic Immunoinflammatory Response Compared to Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fractures","volume":"30","author":"Peker B.","year":"2023","journal-title":"Annals of Medical 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