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In order to identify new potent inhibitors of this enzyme, we describe herein a new structure\u2010based virtual screening (SBVS) using the Institut Curie\u2010CNRS chemical library (ICCL), which contained at the screening date 14307 compounds. The strategy undertaken in this work consisted of the use of several docking programs in SBVS calculations followed by the application of a consensus method (vSDC) and a scrupulous visual analysis. It allowed us to obtain a high degree of success, with a yield of almost 86\u2009%, since 12 hits were identified among only 14 molecules tested <jats:italic>in\u2005vitro<\/jats:italic>. Still more remarkably, 6 of these hits were more active than galantamine, the reference inhibitor. These hits were predicted to have good ADMET properties. The two most promising compounds can serve as leads for AD treatment.<\/jats:p>","DOI":"10.1002\/minf.201800118","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T14:41:36Z","timestamp":1549464096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Identification of New Potent Acetylcholinesterase Inhibitors Using Virtual Screening and <i>in vitro<\/i> Approaches"],"prefix":"10.1002","volume":"38","author":[{"given":"El Hassen","family":"Mokrani","sequence":"first","affiliation":[{"name":"Laboratory of Applied Biochemistry Department of Biochemistry and Cellular and Molecular Biology Faculty of Natural and Life Sciences University Mentouri Brothers Constantine 1  Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahmane","family":"Bensegueni","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry Department of Biochemistry and Cellular and Molecular Biology Faculty of Natural and Life Sciences University Mentouri Brothers Constantine 1  Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Chaput","sequence":"additional","affiliation":[{"name":"Chemistry, Modeling and Imaging for Biology (CMIB) Institut Curie, PSL Research University, CNRS UMR 9187 \u2013 INSERM U1196 Paris-Saclay University  F-91405 Orsay France"},{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301 LabEx LERMIT  91198 Gif-sur-Yvette France"},{"name":"Department of Nephrology and Dialysis, AP-HP Tenon Hospital, INSERM UMR_S 1155  75020 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Beauvineau","sequence":"additional","affiliation":[{"name":"Chemistry, Modeling and Imaging for Biology (CMIB) Institut Curie, PSL Research University, CNRS UMR 9187 \u2013 INSERM U1196 Paris-Saclay University  F-91405 Orsay France"},{"name":"Chemical library Institut Curie-CNRS, UMR9187-U1196 and UMR3666-U1143  F-91405 Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Djeghim","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry Division of Biotechnology and health Biotechnology research Center (CRBt)  Constantine Algeria"},{"name":"Laboratory of Genetics and Biochemistry Plant Biotechnology Faculty of Natural and Life Sciences University Mentouri Brothers Constantine 1  Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Mouawad","sequence":"additional","affiliation":[{"name":"Chemistry, Modeling and Imaging for Biology (CMIB) Institut Curie, PSL Research University, CNRS UMR 9187 \u2013 INSERM U1196 Paris-Saclay University  F-91405 Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1040","volume-title":"Complications in anesthesia.","author":"Michael J. 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