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Preferably, such compounds should possess broad\u2010spectrum antiviral activity, as the development of drugs for the treatment of dozens of viral infections lacking specific treatment would require significant resources. Antiviral activity data present in public resources are very sparse and further investigation of structure\u2010activity relationships is necessary. One of the strategies could be the investigation of chemical space around known active compounds and assessment of activity against closely related viruses in order to fill in the antiviral activity matrix. Here we present an investigation of antiviral activity using universal maps built with generative topographic mapping (GTM) algorithm. The GTM\u2010based maps were used to find commercially available compounds in close proximity to already known compounds with anti\u2010flaviviral and anti\u2010enteroviral activities. Selected compounds were then assessed in cell\u2010based assays against tick\u2010borne encephalitis virus (TBEV) and a panel of enteroviruses. 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