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Research on 3D models of proteins and the search for active molecular sites are important tools to assist in the discovery of effective antiviral drugs to combat COVID\u201019. To address this problem, the 3D protein structures of SARS\u2010CoV 2 were analyzed and submitted to cavities research, evaluation of their druggabillity and liganbility, and applied to molecular docking studies with potential ligand candidates actually assayed against COVID\u201019. Eight druggable potential cavity sites were determined in model structures\u2019 PDB code, 6W4B, 6VWW, 6W01, 6M3M, and 6VYO, and these are the good alternatives to be characterized as targets for antiviral compounds. The good cavity model of the protease 3D structure was used in molecular docking, and this allowed verifying the theoric interactions of this protein and lopinavir and ritonavir antiviral drugs. These results may assist in the use of 3D protein models in drug design studies aiming to develop drugs against the COVID\u201019 pandemic.<\/jats:p>","DOI":"10.1002\/minf.202000096","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T19:54:30Z","timestamp":1596570870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Insights on 3D Structures of Potential Drug\u2010targeting Proteins of SARS\u2010CoV\u20102: Application of Cavity Search and Molecular Docking"],"prefix":"10.1002","volume":"40","author":[{"given":"Mariana S.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Course of Pharmacy Federal University of Pampa (UNIPAMPA).  BR 472, km 592, P.O. 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