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Thus, there is a strong demand for efficient and user\u2010friendly computational tools that allow to analyze large libraries of NPs. In this context, we introduce NP Navigator \u2013 a freely available intuitive online tool for visualization and navigation through the chemical space of NPs and NP\u2010like molecules. It is based on the hierarchical ensemble of generative topographic maps, featuring NPs from the COlleCtion of Open NatUral producTs (COCONUT), bioactive compounds from ChEMBL and commercially available molecules from ZINC. NP Navigator allows to efficiently analyze different aspects of NPs \u2010 chemotype distribution, physicochemical properties, biological activity and commercial availability of NPs. The latter concerns not only purchasable NPs but also their close analogs that can be considered as synthetic mimetics of NPs or pseudo\u2010NPs.<\/jats:p>","DOI":"10.1002\/minf.202100068","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T09:30:16Z","timestamp":1624613416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["NP Navigator: A New Look at the Natural Product Chemical Space"],"prefix":"10.1002","volume":"40","author":[{"given":"Yuliana","family":"Zabolotna","sequence":"first","affiliation":[{"name":"University of Strasbourg Laboratory of Chemoinformatics  4, rue B. 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