{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:53Z","timestamp":1786978253424,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["YY-046"],"award-info":[{"award-number":["YY-046"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Informatics"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    c\u2010Myc is a major oncogene that is estimated to result in almost all human cancers and the c\u2010Myc downregulation has become an attractive strategy for cancer treatment. For it is hard to design compounds that can directly interact with the c\u2010Myc protein, the DNA G\u2010quadruplex (G4) was discovered in its promoter region which was referred to as a potential drug target for controlling c\u2010Myc expression. In this study, a combined strategy of molecular docking\u2010based virtual screening, molecular dynamics (MD) simulation, and molecular mechanics\/generalized Born surface area (MM\/GBSA) free energy calculation was conducted on the existing FDA\u2010Approved Drugs Library, eight compounds were selected for further experimental assay. Among them, five compounds exhibited dose\u2010dependently anticancer activities against RPMI\u20108226 cells with IC\n                    <jats:sub>50<\/jats:sub>\n                    values less than 18.4\u2005\u03bcM. Further experiments showed that Trovafloxacin, Ozanimod, and Ozenoxacin decreased c\u2010Myc mRNA level obviously and downregulated c\u2010Myc expression significantly. In summary, compounds Trovafloxacin, Ozanimod, and Ozenoxacin might be regarded as new c\u2010Myc G4 stabilizers for the treatment of c\u2010Myc related cancers in the future.\n                  <\/jats:p>","DOI":"10.1002\/minf.202200011","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T22:13:24Z","timestamp":1648678404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of Trovafloxacin, Ozanimod, and Ozenoxacin as Potent c\u2010Myc G\u2010Quadruplex Stabilizers to Suppress c\u2010Myc Transcription and Myeloma Growth"],"prefix":"10.1002","volume":"41","author":[{"given":"Jinyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu 221004 P. R. 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