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In the cosmetic field, they remain the major elements of the composition and serve as marketing asset. Recent research showed the implication of salt\u2010inducible kinases on the melanin production in skin via MITF regulation. Finding new potent modulators on such target could open the way to several cosmetic applications to attenuate visible signs of photoaging and improve the tan without sun. Since virtual screening can be a powerful tool for detecting hit compounds in the early stages of a drug discovery process, we applied this method on salt\u2010inducible kinase 2 to discover potential interesting compounds. Here, we present the different steps from the construction of a database of natural products, to the validation of a docking protocol and the results of the virtual screening. Hits from the screening were tested <jats:italic>in\u2005vitro<\/jats:italic> to confirm their efficiency and results are discussed.<\/jats:p>","DOI":"10.1002\/minf.202300335","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T14:54:05Z","timestamp":1718204045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Virtual screening of natural products to enhance melanogenosis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-4110","authenticated-orcid":false,"given":"Colin","family":"Bournez","sequence":"first","affiliation":[{"name":"Institut de Chimie Organique et Analytique (ICOA) UMR CNRS-Universit\u00e9 d'Orl\u00e9ans 7311, Universit\u00e9 d'Orl\u00e9ans BP 6759  45067 Orl\u00e9ans Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u2010Manuel","family":"Gally","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique (ICOA) UMR CNRS-Universit\u00e9 d'Orl\u00e9ans 7311, Universit\u00e9 d'Orl\u00e9ans BP 6759  45067 Orl\u00e9ans Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-7924","authenticated-orcid":false,"given":"Samia","family":"Aci\u2010S\u00e8che","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique (ICOA) UMR CNRS-Universit\u00e9 d'Orl\u00e9ans 7311, Universit\u00e9 d'Orl\u00e9ans BP 6759  45067 Orl\u00e9ans Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bernard","sequence":"additional","affiliation":[{"name":"Greenpharma SAS, 3, all\u00e9e du Titane  45100 Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique (ICOA) UMR CNRS-Universit\u00e9 d'Orl\u00e9ans 7311, Universit\u00e9 d'Orl\u00e9ans BP 6759  45067 Orl\u00e9ans Cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802926-8.00001-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-022-00363-y"},{"key":"e_1_2_9_4_1","unstructured":"\u201cSkin care industry: global skincare market size 2012\u20132024 \u201d can be found underhttps:\/\/www.statista.com\/statistics\/254612\/global-skin-care-market-size\/(accessed: October 9 2023)."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2016.03.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00226.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480680"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.045"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.3.827"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071144"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.413"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092668"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302185"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00760.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.042"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.08.004"},{"key":"e_1_2_9_18_1","first-page":"339","volume":"4","author":"Emerald M.","year":"2016","journal-title":"Pharm. 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