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Hence, understanding and predicting such mutations is crucial for developing effective PCa treatment strategies. Leveraging accu\u2010 mulated data on clinically relevant AR mutants with recent advances in deep modeling techniques, this study aims to unveil and quantify critical AR mutation\u2010drug relation\u2010 ships. By incorporating molecular descriptors for drugs and mutated genes sequences, this work represented these features as single vectors and demonstrates their effective\u2010 ness in modeling AR mutant responses to conventional antiandrogens. The developed approach achieves above 80% accuracy in predicting the gain\u2010of\u2010function behavior of AR mutants and therefore can potentially uncover unknown agonist\/antagonist relationships among mutant\u2010drug pairs.<\/jats:p>","DOI":"10.1002\/minf.202500018","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T20:52:54Z","timestamp":1746046374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Modeling of Gain\u2010of\u2010Function Mutations on Androgen Receptor"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-7403","authenticated-orcid":false,"given":"Jiaying","family":"You","sequence":"first","affiliation":[{"name":"Department of Urologic Sciences Faculty of Medicine Vancouver Prostate Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Foo","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences Faculty of Medicine Vancouver Prostate Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Lallous","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences Faculty of Medicine Vancouver Prostate Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem","family":"Cherkasov","sequence":"additional","affiliation":[{"name":"Department of Urologic Sciences Faculty of Medicine Vancouver Prostate Centre University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8030028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S153764"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.08.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3353727"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20137163.MCT-22\u20130237"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.18"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2020.03.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1815671"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903307"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143488"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052493"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","unstructured":"Cherkasov A Muratov EN Fourches D Varnek A Baskin II Cronin M Dearden J Gramatica P Martin YC Todeschini R Consonni V. 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