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In parallel, multiple research groups have been collaborating and assembling a unified Latin American Natural Product Database (LANaPDB), an open\u2010access compound collection representative of Latin America that stands out as a geographical region distinct from its vastness and richness of NP resources. Herein, we report a significant update of LANaPDB, which gathers NPs from eight countries. Major updates to the database include adding 1,164 new compounds obtained from NaturAr, a NP collection from Argentina published in 2025, and 132 new compounds from Panama. The updated LANaPDB has 14,742 nonduplicate compounds. Moreover, a comprehensive evaluation of 41 ADMET (absorption, distribution, metabolism, excretion, and toxicity)\u2010related parameters was carried out for LANaPDB, and the results were compared with one of the largest NP databases, the Universal Natural Product Database, and the approved small\u2010molecule drugs. The results indicated that the three databases have a very similar ADMET profile. Besides, most of the LANaPDB compounds presented high bioavailability, volume of distribution, plasma protein binding rate, blood\u2013brain barrier penetration, susceptibility to CYP3A4, and half\u2010life less than 12\u2009h. Moreover, most of the LANaPDB compounds were predicted with a low probability of inducing toxicity\u2010related reactions. The third version of LANaPDB and the codes for the curation and determination of 41 ADMET\u2010related parameters are freely available at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.5281\/zenodo.15595030\">https:\/\/doi.org\/10.5281\/zenodo.15595030<\/jats:ext-link>\n                    . 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