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However, the intricate interactions between the fungus and the host remain poorly understood, and a comprehensive inventory of fungal virulence factors has yet to be established. In this study, we identified a <jats:italic>C. albicans<\/jats:italic> secretory effector protein Sce1, whose induction and secretion are associated with vagina\u2010simulative conditions and chlamydospore formation. Sequence alignment showed that Sce1 belongs to a Pir family in <jats:italic>C. albicans<\/jats:italic>, which is conserved across several fungi and primarily characterized as a \u03b2\u2010glucan binding protein in the <jats:italic>Saccharomyces\u00a0cerevisiae<\/jats:italic>. Mechanically, Sce1 is primarily localized to the cell wall in a cleaved form as an alkali\u2010labile \u03b2\u20101,3\u2010glucan binding protein and plays a role in masking \u03b2\u2010glucan in acidic environments and chlamydospores, a feature that might underline <jats:italic>C. albicans<\/jats:italic>' ability to evade host immunity. Further, a cleaved short form of Sce1 protein could be released into extracellular compartments and presented in bone marrow\u2010derived macrophages infected with chlamydospores. This cleaved short form of Sce1 also demonstrated a unique ability to trigger the caspases\u20108\/9\u2010dependent apoptosis in various host cells. Correspondingly, genetic deletion of <jats:italic>SCE1<\/jats:italic> led to dampened vaginal colonization of <jats:italic>C. albicans<\/jats:italic> and diminished fungal virulence during systemic infection. The discovery of Sce1 as a versatile virulence effector that executes at various compartments sheds light on the fungus\u2013host interactions and <jats:italic>C. albicans<\/jats:italic> pathogenesis.<\/jats:p>","DOI":"10.1002\/mlf2.12066","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T11:59:45Z","timestamp":1687780785000},"page":"159-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The secretory <i>Candida<\/i> effector Sce1 licenses fungal virulence by masking the immunogenic \u03b2\u20101,3\u2010glucan and promoting apoptosis of the host cells"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-2734","authenticated-orcid":false,"given":"Hongyu","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular 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