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In this study, we performed the first genome\u2010wide scanning of ERV loci in the American mink (<jats:italic>Neogale vison<\/jats:italic>) genome (NeoERV) followed by transcriptomic analysis to detect actively transcribed NeoERV elements. A total of 365,791 NeoERV loci were identified, and161,205 (44%) of these loci were found to be actively transcribed based on transcriptomic data from three types of tissues (amygdala, trachea and lung). More than one third of the actively transcribed NeoERV loci were tissue\u2010specific. Furthermore, some of the active loci were associated with host gene transcription, and the level of NeoERV transcription was positively correlated with that of host genes, specifically when active loci were located in overlapped gene regions. An in\u2010depth analysis of the envelope protein coding <jats:italic>env<\/jats:italic> gene showed that, in general, its transcription level was higher than that of NeoERVs, which is believed to be associated with host immunity.<\/jats:p>","DOI":"10.1002\/mlf2.12074","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T08:55:04Z","timestamp":1688115304000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010wide identification of endogenous retrovirus elements and their active transcription in mink genome"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-6244","authenticated-orcid":false,"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of Microbiology, Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of Microbiology, Chinese Academy of Sciences  Beijing China"},{"name":"Jiangxi Science and Technology Normal University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Lv","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of Microbiology, Chinese Academy of Sciences  Beijing China"},{"name":"Jinan Microecological Biomedicine Shandong Laboratory  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojin","family":"Xu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of Microbiology, Chinese Academy of Sciences  Beijing 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