{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:07:20Z","timestamp":1785769640577,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["mLife"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Impact Statement<\/jats:title><jats:p>Invasive nontyphoidal <jats:italic>Salmonella<\/jats:italic> (iNTS) causes significant concern with ~15% morbidity, affecting populations mainly in African countries. However, iNTS infections among the Chinese pediatric population remain largely unknown. Here, we conducted a genomic investigation to study pediatric iNTS infections in a Chinese hospital. iNTS isolates accounted for 15.2% (18\/119) of all nontyphoidal <jats:italic>Salmonella<\/jats:italic> (NTS) strains. Compared to non\u2010iNTS isolates, iNTS isolates harbored a lower prevalence of antimicrobial\u2010resistant genes of fluoroquinolones and \u03b2\u2010lactams, as well as disinfectant determinants and plasmids, but carried a significantly higher prevalence of <jats:italic>cdtB<\/jats:italic>, <jats:italic>faeCDE<\/jats:italic>, and <jats:italic>tcpC<\/jats:italic> genes. Importantly, we detected an emerging serovar Goldcoast as the predominant iNTS serovar locally. By integrating 320 global Goldcoast genomes based on the One Health samplings, we conducted nationwide phylogenomic tracking and detected repeated human\u2010to\u2010human transmission events among iNTS cases caused by an underestimated serovar Goldcoast. Together, our exploratory genomic approach highlights a new trend in pediatric iNTS infections.<\/jats:p>","DOI":"10.1002\/mlf2.12117","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T16:09:19Z","timestamp":1711728559000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Genomic investigation and nationwide tracking of pediatric invasive nontyphoidal <i>Salmonella<\/i> in China"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-4583","authenticated-orcid":false,"given":"Yefang","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Ningbo Women and Children's Hospital Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Zhejiang University College of Animal 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temporal dynamics of antimicrobial\u2010resistant Salmonella enterica and predominant serovars in China","author":"Wang Y","year":"2023","journal-title":"Natl Sci 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