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However, the underlying mechanisms of real\u2010world pathogen\u2013host interactions remain elusive, in part due to the lack of powerful immunocompetent animal models. Here, we report that selected wild\u2010type strains of\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    can be developed as a promising infection model to recapitulate\n                    <jats:italic>C. auris<\/jats:italic>\n                    systemic infection. The systemic and organ\u2010specific responses to\n                    <jats:italic>C. auris<\/jats:italic>\n                    infection\n                    <jats:italic>in vivo<\/jats:italic>\n                    were evaluated, as well as the corresponding transcriptional profiling. Our findings confirmed that Toll and JAK\u2010STAT signaling pathways mediate antifungal responses in the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    model following\n                    <jats:italic>C. auris<\/jats:italic>\n                    infection. Moreover, we identified certain conserved novel factors required for host\u2013\n                    <jats:italic>C. auris<\/jats:italic>\n                    interactions, highlighting the fly model's potential to reveal subtle immune mechanisms not readily observed in mammalian systems. Taken together, our work demonstrates that wild\u2010type\n                    <jats:italic>Drosophila<\/jats:italic>\n                    offers a robust immunocompetent animal model for further in\u2010depth investigation of dynamic\n                    <jats:italic>C. auris<\/jats:italic>\n                    \u2013host interactions\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/mlf2.70038","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:39:46Z","timestamp":1771501186000},"page":"51-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Profiling the host defense responses against\n                    <i>Candida auris<\/i>\n                    in a reliable\n                    <i>Drosophila melanogaster<\/i>\n                    infection 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