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However, the physiological significance of this reduction process remains poorly understood, because\n                    <jats:italic>Shewanella<\/jats:italic>\n                    species are capable of reducing only low concentrations of iodate. This study systematically examined the physiological and transcriptomic responses of\n                    <jats:italic>Shewanella oneidensis<\/jats:italic>\n                    MR\u20101 to iodate exposure. Our results showed that phenol\u2010mediated elimination of hypoiodous acid did not increase the upper limit of iodate reduction achieved by\n                    <jats:italic>S. oneidensis<\/jats:italic>\n                    MR\u20101, and dimethyl sulfoxide was preferentially utilized over iodate by the organism. When iodate served as the sole electron acceptor, no increase in total cellular protein was observed in\n                    <jats:italic>S. oneidensis<\/jats:italic>\n                    MR\u20101, in contrast to marine\n                    <jats:italic>Shewanella<\/jats:italic>\n                    strains, which exhibited increased production of total cellular protein at 0.25 and 0.50\u2009mM iodate. Furthermore, anaerobic growth of\n                    <jats:italic>S. oneidensis<\/jats:italic>\n                    MR\u20101 and the \u0394\n                    <jats:italic>dmsEFAB<\/jats:italic>\n                    strain was dose\u2010dependently inhibited by iodate, which induced significant oxidative stress. Transcriptomic analysis revealed that the mRNA levels of\n                    <jats:italic>mtrCAB<\/jats:italic>\n                    and several genes encoding antioxidant enzymes were elevated during iodate reduction. Deletion mutants of\n                    <jats:italic>so1563<\/jats:italic>\n                    (glutathione peroxidase),\n                    <jats:italic>so1659<\/jats:italic>\n                    (\n                    <jats:italic>c<\/jats:italic>\n                    \u2010type cytochrome), and\n                    <jats:italic>so0534<\/jats:italic>\n                    (arsenate permease) exhibited reduced capacities for iodate reduction or H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    degradation. Notably, supplementation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    in the medium compromised iodate reduction in both wild\u2010type and mutant strains. Collectively, these findings provide evidence that iodate reduction in\n                    <jats:italic>Shewanella<\/jats:italic>\n                    primarily functions as a detoxification mechanism rather than a process for energy conservation. The results further highlight distinct adaptive strategies employed by\n                    <jats:italic>Shewanella<\/jats:italic>\n                    species in freshwater and marine environments with different iodine concentrations.\n                  <\/jats:p>","DOI":"10.1002\/mlf2.70096","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:46:46Z","timestamp":1787554006000},"page":"507-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elucidating the physiological significance of iodate reduction in\n                    <i>Shewanella<\/i>\n                    species"],"prefix":"10.1002","volume":"5","author":[{"given":"Ziyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biological Sciences and Technology School of Environmental Studies, China University of Geosciences Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Technology School of Environmental Studies, China University of Geosciences Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Technology School of Environmental Studies, China University of Geosciences Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Technology School of Environmental Studies, China University of Geosciences Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Technology School of Environmental 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