{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:24:13Z","timestamp":1792056253923,"version":"4.4.0"},"reference-count":110,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T00:00:00Z","timestamp":1158192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The contaminant 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin (TCDD) is a prototype compound of a whole class of halogenated aromatic hydrocarbons termed \u2018dioxinlike\u2019 contaminants present in food, human tissue, mothers milk, and environmental samples. Among the various adverse effects caused by TCDD in animal experiments, its carcinogenic effects caused particular concern. In rodents, long\u2010term TCDD treatment leads to the development of tumors of the liver, thyroid, lung, skin, oral cavity and other sites. The occurrence of liver tumors mainly observed in female rats has been used as a basis for quantitative cancer risk assessment for TCDD. TCDD does not behave like a \u2018complete carcinogen\u2019, <jats:italic>i.\u00a0e<\/jats:italic>. no DNA binding of the parent compound or metabolites thereof could be detected. However, enhanced oxidative damage of hepatic DNA was observed, probably resulting from a dramatic induction of cytochrome P450 enzymes, which are under the regulatory, transcriptional control of the TCDD\u2010activated aryl hydrocarbon receptor. The marked enhancement of TCDD\u2010related oxidative liver DNA damage in rats by estrogens warrants further mechanistic investigation. Furthermore, TCDD acts as a tumor promoter,<jats:italic> i.\u00a0e<\/jats:italic>. it facilitates the growth of putative preneoplastic hepatic lesions after initiation with a complete carcinogen. The mechanisms underlying this effect may be related to altered intracellular signaling involving pronounced changes in the phosphorylation pattern of proteins regulating growth and apoptosis. These effects are thought to result in an enhanced survival of preneoplastic cells, some of which can undergo further steps on the way to malignancy. In summary, a better understanding of the mechanisms of the carcinogenicity of TCDD is mandatory to provide a rational basis for a better inter\u2010species extrapolation. The final aim of these efforts is a more reliable risk assessment for the carcinogenic potency of the class of dioxinlike contaminants in humans.<\/jats:p>","DOI":"10.1002\/mnfr.200600006","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T16:23:56Z","timestamp":1158251036000},"page":"897-907","source":"Crossref","is-referenced-by-count":156,"title":["Carcinogenicity of 2,3,7,8\u2010tetrachlorodibenzo\u2010<i>p<\/i>\u2010dioxin in experimental models"],"prefix":"10.1002","volume":"50","author":[{"given":"Stefanie","family":"Knerr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Schrenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106775"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(77)90107-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(78)90075-3"},{"key":"e_1_2_1_5_2","unstructured":"NTP. United States National Toxicology Program. Tech. Rep. 1982 Series No.209; DHEW publication No. (NIH) 82\u20131765 Research Triangle Park NC."},{"key":"e_1_2_1_6_2","unstructured":"NTP. United States National Toxicology Program. Tech. Rep. 2005 Series No.521; Draft Abstract Research Triangle Park NC."},{"key":"e_1_2_1_7_2","unstructured":"NTP. United States National Toxicology Program. Tech. Rep. 1982b Series No.201; DHEW publication No. (NIH) 82\u20131757 Research Triangle Park NC."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/278548a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/030089168707300203","volume":"73","author":"Della Porta G.","year":"1987","journal-title":"Tumori"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/9.9.1677"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/026520300283360"},{"key":"e_1_2_1_12_2","unstructured":"Clark G. C. Tritscher A. Maronpot R. Foley J. Lucier G. W. Tumor promotion by TCDD in female rats in: Gallo M. A. Scheuplein R. J. van der Heijden K. A. (Eds.) Biological Basis for Risk Assessment of Dioxins and Related Compounds (Banbury Report 35) CSH Press Cold Spring Harbor NY 1991 pp. 389\u2013404."},{"key":"e_1_2_1_13_2","first-page":"3616","volume":"40","author":"Pitot H. C.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.10.1491"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(91)90122-K"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(91)90093-J"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1991.tb01328.x"},{"key":"e_1_2_1_18_2","first-page":"1391","volume":"51","author":"Lucier G. W.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/13.8.1389"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.93101634"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.6.1143"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.3.509"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/019262339402200305"},{"key":"e_1_2_1_24_2","first-page":"241","volume":"292","author":"Hemming H.","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.6.1271"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.11.2807"},{"key":"e_1_2_1_27_2","first-page":"101","volume":"20","author":"Berry D. L.","year":"1978","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/300271a0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90033-Q"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.6.1345"},{"key":"e_1_2_1_31_2","first-page":"4875","volume":"55","author":"Beebe L. E.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90084-X"},{"key":"e_1_2_1_33_2","first-page":"5617","volume":"52","author":"Eldridge S. R.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(94)90403-0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(89)90104-2"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00203568"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.744"},{"key":"e_1_2_1_38_2","unstructured":"IARC. International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Polychlorinated Dibenzo\u2010p\u2010dioxins and Polychlorinated Dibenzofurans Lyon 1997 Vol. 69."},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.17.8185"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91185-S"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31725-3"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"28098","DOI":"10.1016\/S0021-9258(18)46900-1","volume":"269","author":"Li H.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.12.8343"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00301-0"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152706299"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0875"},{"key":"e_1_2_1_47_2","first-page":"6911","volume":"60","author":"Viluksela M.","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2322"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx000266j"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/68.2.295"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a024245"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500183"},{"key":"e_1_2_1_53_2","unstructured":"Cavalieri E. Frenkel K. Liehr J. G. Rogan E. Roy D. J. Nat. Cancer Inst. Monogr. No. 27 75\u201393."},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh200"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.12.003"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(96)00451-1"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90250-I"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-101-1-292"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00381a018"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90175-4"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1104"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(89)90004-5"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(89)90231-7"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/65.2.184"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/3.10.1187"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(88)90267-0"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(89)90141-8"},{"key":"e_1_2_1_68_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/jn\/119.4.573","volume":"119","author":"Hakansson H.","year":"1989","journal-title":"J. Nutr."},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570050304"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(90)90007-A"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.37.117"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.37.239"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0045-6535(95)00365-7"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0626-4"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00640.x"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90324-2"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7407"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(89)90174-9"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.9.1885"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/13.3.453"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.1.27"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.3.479"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050600"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90337-T"},{"key":"e_1_2_1_85_2","doi-asserted-by":"crossref","first-page":"9591","DOI":"10.1016\/S0021-9258(18)92861-9","volume":"266","author":"Choi E. J.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925598"},{"key":"e_1_2_1_87_2","doi-asserted-by":"crossref","first-page":"24591","DOI":"10.1016\/S0021-9258(18)35805-8","volume":"267","author":"Gaido K. W.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_88_2","first-page":"142","volume":"11","author":"D\u00f6hr O.","year":"1994","journal-title":"Exp. Clin. Immunogenet."},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0060"},{"key":"e_1_2_1_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.3.443"},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90089-2"},{"key":"e_1_2_1_92_2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1096\/fasebj.6.2.1311272","volume":"6","author":"Puga A.","year":"1992","journal-title":"FASEB J."},{"key":"e_1_2_1_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(85)80158-3"},{"key":"e_1_2_1_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.11.2283"},{"key":"e_1_2_1_95_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1994.1011"},{"key":"e_1_2_1_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570090207"},{"key":"e_1_2_1_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570090308"},{"key":"e_1_2_1_98_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/taap.2002.9475","volume":"183","author":"Dietrich C.","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"e_1_2_1_99_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20067"},{"key":"e_1_2_1_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0624-6"},{"key":"e_1_2_1_101_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2587"},{"key":"e_1_2_1_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(98)00040-4"},{"key":"e_1_2_1_103_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.000356"},{"key":"e_1_2_1_104_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.0782"},{"key":"e_1_2_1_105_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2943"},{"key":"e_1_2_1_106_2","first-page":"8534","volume":"61","author":"Kolluri S. K.","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_1_107_2","first-page":"273","volume":"146","author":"Schulte\u2010Hermann R.","year":"1999","journal-title":"IARC Sci. Publ."},{"key":"e_1_2_1_108_2","first-page":"1271","volume":"56","author":"Woerner W.","year":"1996","journal-title":"Cancer Res."},{"key":"e_1_2_1_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.09.002"},{"key":"e_1_2_1_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh289"},{"key":"e_1_2_1_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.10.2321"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.200600006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.200600006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T23:59:26Z","timestamp":1694476766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.200600006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,28]]},"references-count":110,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1002\/mnfr.200600006"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.200600006","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,28]]}}}