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Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards<jats:italic>Helicobacter pylori<\/jats:italic>, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP\u20101 and inducible NF\u2010\u03ba\u03b2 transcriptions as well as the inflammatory biomarker IL\u20108, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell\u2010induced tumor growth in an<jats:italic>in vivo<\/jats:italic>model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.<\/jats:p>","DOI":"10.1002\/mnfr.200700002","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T13:20:42Z","timestamp":1180444842000},"page":"675-683","source":"Crossref","is-referenced-by-count":749,"title":["Berry anthocyanins as novel antioxidants in human health and disease prevention"],"prefix":"10.1002","volume":"51","author":[{"given":"Shirley","family":"Zafra\u2010Stone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taharat","family":"Yasmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manashi","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe A.","family":"Vinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasis","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,29]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"145","article-title":"Vegetables, fruits and phytoestrogens in the prevention of diseases","volume":"50","author":"Heber D.","year":"2004","journal-title":"J. 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