{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:49:24Z","timestamp":1790869764739,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T00:00:00Z","timestamp":1188345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ARC"},{"name":"AUF, \u2018Ligue Nationale Fran\u00e7aise contre le cancer\u2019"},{"name":"EU"},{"DOI":"10.13039\/501100013415","name":"R\u00e9gion Midi-Pyr\u00e9n\u00e9es","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013415","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Concerted Action \u2018Pavle Savic\u2019 France-Serbia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To find out whether ochratoxin A (OTA), citrinin (CIT), aristolochic acids (AA) are etiologic agents of Balkan endemic nephropathy (BEN) or Chinese herbal nephrotoxicity, and associated urinary tract tumor (UTT), we have compared (i) in human kidney cell culture, the DNA adduct formation and persistence of OTA\/CIT and AA adducts (ii) analyzed DNA adduct in several tumors from human kidney suspected to be exposed to either OTA and CIT, or AAs (iii) analyzed OTA, CIT, and AA in food. In kidney cell cultures, formation of specific OTA\u2010DNA adduct and AA\u2010DNA adduct were detected in the same range (around 10 adducts\/10<jats:sup>9<\/jats:sup>nucleotides) and were time\u2010 and dose\u2010dependent. After 2 days all disappeared. DNA adduct related to OTA and CIT are found in human kidney tissues from Balkans, France, and Belgium whereas no DNA adducts related to AA could be found in any tumors of BEN patients from Croatia, Bulgaria, or Serbia. No DNA adduct was found in kidney biopsy or necropsy of the French women suspected to be exposed to AA. OTA and CIT are more frequently found in rural area. AA was never detected. All these plead for implication of mycotoxins, especially OTA, in BEN and UTT.<\/jats:p>","DOI":"10.1002\/mnfr.200700045","type":"journal-article","created":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T14:48:04Z","timestamp":1188398884000},"page":"1131-1146","source":"Crossref","is-referenced-by-count":117,"title":["New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor"],"prefix":"10.1002","volume":"51","author":[{"given":"Annie","family":"Pfohl\u2010Leszkowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Tozlovanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Manderville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Peraica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Castegnaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Stefanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190102"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/02652030110079815"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090705"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200600137"},{"key":"e_1_2_1_6_2","unstructured":"Akhmeteli M. A. Epidemiology of endemic nephropathy in: Bulgarian Academy of Sciences (Ed.) Endemic Nephropathy Proceedings of the Second International Symposium on Endemic Nephropathy 9\u201312 November 1972 Sofia Bulgaria 1972 pp. 19\u201323."},{"key":"e_1_2_1_7_2","first-page":"114","article-title":"Upper urothelial tumors and Balkan endemic nephropathy\u2010 dose responsible diseases, Facta Univ.","volume":"9","author":"Nikolic J.","year":"2002","journal-title":"Ser. Med. Biol."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/02652038509373555"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","unstructured":"Petkova\u2010Bocharova T. Castegnaro M. Michelon J. Maru V. Ochratoxin A and other mycotoxins in cereals from an area of Balkan endemic nephropathy and urinary tract tumours in Bulgaria in: Castegnaro M. Plestina R. Dirheimer G. Chernozemsky I. N. Bartsch H. (Eds.) Mycotoxins Endemic Nephropathy and Urinary Tract Tumours IARC Sci. Publ.No. 115 Lyon IARC 1991. pp. 83\u201387.","DOI":"10.1016\/0277-5379(91)91350-R"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf990891y"},{"key":"e_1_2_1_11_2","first-page":"129","article-title":"Ochratoxin A concentration in food and feed from a region with Balkan endemic nephropathy","volume":"9","author":"Abouzied M. M.","year":"2002","journal-title":"Facta Univ.: Ser. Med. Biol."},{"key":"e_1_2_1_12_2","first-page":"245","article-title":"Synergistic effect of citrinin on hepatorenal carcinogenesis of ochratoxin A in mice","volume":"7","author":"Kanisawa M.","year":"1984","journal-title":"Dev. Food Sci."},{"key":"e_1_2_1_13_2","first-page":"269","article-title":"Cumulative effect of ochratoxin A and citrinin on induction of hepatorenal carcinogenesis in mice (Mus musculus)","volume":"52","author":"Jeswal P.","year":"1995","journal-title":"Biomed. Lett."},{"key":"e_1_2_1_14_2","first-page":"29","article-title":"The problem of etiology of endemic nephropathy","volume":"1","author":"Ivic M.","year":"1970","journal-title":"Acta Fac. Med. Naissensis"},{"key":"e_1_2_1_15_2","first-page":"116","article-title":"Endemic nephropathy: The case for Chronic poisonning by Aristolochia","volume":"46","author":"Hranjec T.","year":"2005","journal-title":"Croat. Med. J."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006083422301"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20316"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90964-4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92984-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx049877s"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx060138g"},{"key":"e_1_2_1_22_2","first-page":"15","article-title":"Insuffisance r\u00e9nale terminale associ\u00e9e \u00e0 la consommation d'herbes chinoises en France","volume":"19","author":"Stengel B.","year":"1998","journal-title":"N\u00e9phrologie"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/02652030500309400"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.06.035"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500182"},{"key":"e_1_2_1_26_2","first-page":"237","article-title":"Toxicological considerations in the application and interpretation of DNA adducts in epidemiological studies","volume":"157","author":"Swenberg J. A.","year":"2004","journal-title":"IARC Sci. Publ."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00022-6"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.10.010"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.353"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4639-00088"},{"key":"e_1_2_1_31_2","first-page":"1039","article-title":"Adenomas induced by polycyclic aromatic hydrocarbons in strain A\/J mouse lung correlate with time integrated DNA adduct level","volume":"55","author":"Ross J. A.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.10.1955"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203286"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00093.x"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.06.014"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980703)77:1<70::AID-IJC12>3.0.CO;2-D"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2744(199810)23:2<76::AID-MC4>3.0.CO;2-B"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200400062"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.5900"},{"key":"e_1_2_1_40_2","unstructured":"Wiessler M. DNA adducts of pyrrolizidine alkaloids nitroimidazoles and aristolochic acid in: Hemminki K. Dipple A. Shuker D. B. G. Kadulubar F. P. et al.(Eds.) DNA Adducts: Identification and Biological Significance IARC Sci. Publ.1994 125 165\u2013177."},{"key":"e_1_2_1_41_2","first-page":"217","article-title":"Implications of results of molecular epidemiology on DNA adducts, their repair and mutations for mechanisms of human cancer","volume":"157","author":"Hemminki K.","year":"2004","journal-title":"IARC Sci. Publ."},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.6.471"},{"key":"e_1_2_1_43_2","first-page":"179","article-title":"Risk assessment of the mycotoxin ochratoxin A","volume":"2","author":"Kuiper\u2010Goodman T.","year":"1989","journal-title":"Biomed. Environ. Sci."},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1998.tb00822.x"},{"key":"e_1_2_1_45_2","doi-asserted-by":"crossref","unstructured":"Pfohl\u2010Leszkowicz A. Vrabcheva T. Petkova\u2010Bocharova T. Garren L. et al. Analysis of ochratoxin a in serum urine and food consumed by inhabitants from an area with Balkan endemic nephropathy: A 1\u2009month follow up study in: Njapau H. Trujillio S. Van Egmond H. P. Park D. L. (Eds.) Mycotoxins and Phycotoxins Proceeding of the XIth International IUPAC Symposium on Mycotoxins and Phycotoxins May 17\u201321 2004 Wageningen Academic Publishers Bethesda Maryland USA 2006 pp. 217\u2013224.","DOI":"10.3920\/9789086865857_023"},{"key":"e_1_2_1_46_2","unstructured":"Castegnaro M. Maru V. Petkova\u2010Bocharova T. Nikolov I. Bartsch H. Concentration of ochratoxin A in the urine of endemic nephropathy patients and controls in Bulgaria: Lack of detection of 4\u2010hydroxyochratoxin A in: Castegnaro M. Plestina R. Dirheimer G. Chernozemsky I. N. Bartsch H. (Eds.) Mycotoxins. Endemic Nephropathy and Urinary Tract Tumours IARC Sci. Publ.1991 115 165\u2013169."},{"key":"e_1_2_1_47_2","first-page":"62","article-title":"Analysis of ochratoxin A in serum and urine of inhabitants from an area with Balkan Endemic Nephropathy: A one month follow up study","volume":"10","author":"Petkova\u2010Bocharova T.","year":"2003","journal-title":"Facta Univ.: Ser. Med. Biol."},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00028-1"},{"key":"e_1_2_1_49_2","first-page":"33","article-title":"High affinity binding of ochratoxin A to plasma constituents","volume":"9","author":"Stojkovic R.","year":"1984","journal-title":"Biochem. Int."},{"key":"e_1_2_1_50_2","doi-asserted-by":"crossref","unstructured":"Pfohl\u2010Leszkowicz A. Molini\u00e9 A. Tozlovanu M. Manderville R. A. Combined toxic effects of ochratoxin A and citrinin in vitro and in vivo Proceeding of the ACS meeting 2007 September 2006 San Francisco USA (in press).","DOI":"10.1021\/bk-2008-1001.ch003"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/02652030110113726"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/0265203021000012376"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1080\/01448765.2003.9754976"},{"key":"e_1_2_1_54_2","unstructured":"Pfohl\u2010Leszkowicz A. Grosse Y. Castegnaro M. Petkova\u2010Bocharova T. et al. Ochratoxin A related DNA adducts in urinary tract tumours of Bulgarian subjects in: Phillips D. H. Castegnaro M. Barstch H. (Eds.) Postlabeling Methods for Detection of DNA Adducts IARC Sci. Publ.1993 124 141\u2013148."},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00731.x"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.12.004"},{"key":"e_1_2_1_57_2","unstructured":"IARC Monograph on the evaluation of carcinogenic risks to human: Some traditional herbal medicines some mycotoxins Naphtalene and styrene IARC Monographs2002 82 68\u2013128."}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.200700045","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.200700045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.200700045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T17:20:40Z","timestamp":1708190440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.200700045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1002\/mnfr.200700045"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.200700045","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}