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Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic complications of atherosclerosis. These new findings provide important links between risk factors and the mechanisms of atherogenesis and garlic properties. Numerous<jats:italic> in vitro<\/jats:italic> studies have confirmed the ability of garlic to reduce the parameters of the risk of atherosclerosis: total cholesterol, LDL, triglycerides, oxidized LDL. Bioactive compounds and antioxidant potentials in fresh, cooked, boiled and commercial garlic from different regions are presented, using \u03b2\u2010carotene, 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH), nitric oxide (NO), 2,2\u2032\u2010azinobis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) diammonium salt (ABTS) with K<jats:sub>2<\/jats:sub>S<jats:sub>2<\/jats:sub>O<jats:sub>8 <\/jats:sub>or MnO<jats:sub>2<\/jats:sub>, ferric\u2010reducing\/antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC) and others assays for antioxidant status. <jats:italic>In vivo<\/jats:italic> studies were reviewed on with garlic and cholesterol supplemented diets. The positive influences of garlic on plasma lipids, proteins, antioxidant activity, and some indices of blood coagulation are dose dependent. Garlic could be a valuable component of atherosclerosis\u2010preventing diets only in optimal doses. Many recently published reports show that garlic possesses plasma lipid\u2010lowering and plasma anticoagulant and antioxidant properties and improves impaired endothelial function.<\/jats:p>","DOI":"10.1002\/mnfr.200700064","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T00:46:21Z","timestamp":1210812381000},"page":"1365-1381","source":"Crossref","is-referenced-by-count":64,"title":["The atherosclerotic heart disease and protecting properties of garlic: contemporary data"],"prefix":"10.1002","volume":"51","author":[{"given":"Shela","family":"Gorinstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenon","family":"Jastrzebski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Namiesnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Leontowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Leontowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Trakhtenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602203140806"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_2_1_4_2","first-page":"589S","article-title":"Dietary protein, cholesterol and atherosclerosis: a review of the early history","volume":"125","author":"Kritchevsky D.","year":"1995","journal-title":"J. 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