{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:46:40Z","timestamp":1779911200184,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T00:00:00Z","timestamp":1191456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this review is to update and assess the clinical evidence based on rigorous trials of the effectiveness of garlic (<jats:italic>A. sativum<\/jats:italic>). Systematic searches were carried out in Medline, Embase, Amed, the Cochrane Database of Systematic Reviews, Natural Standard, and the Natural Medicines Comprehensive Database (search date December 2006). Our own files, the bibliographies of relevant papers and the contents pages of all issues of the review journal FACT were searched for further studies. No language restrictions were imposed. To be included, trials were required to state that they were randomized and double blind. Systematic reviews and meta\u2010analyses of garlic were included if based on the results of randomized, double\u2010blind trials. The literature searches identified six relevant systematic reviews and meta\u2010analysis and double\u2010blind randomized trials (RCT) that were published subsequently. These relate to cancer, common cold, hypercholesterolemia, hypertension, peripheral arterial disease and pre\u2010eclampsia. The evidence based on rigorous clinical trials of garlic is not convincing. For hypercholesterolemia, the reported effects are small and may therefore not be of clinical relevance. For reducing blood pressure, few studies are available and the reported effects are too small to be clinically meaningful. For all other conditions not enough data are available for clinical recommendations.<\/jats:p>","DOI":"10.1002\/mnfr.200700073","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T14:16:38Z","timestamp":1191507398000},"page":"1382-1385","source":"Crossref","is-referenced-by-count":73,"title":["Clinical effectiveness of garlic (<i>Allium sativum<\/i>)"],"prefix":"10.1002","volume":"51","author":[{"given":"Max H.","family":"Pittler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edzard","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,26]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Blumenthal M. 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Garlic: the science and therapeutic application of Allium sativum L. and related species Williams & Wilkins Baltimore 1996."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.4.1047"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.3.821S"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.3.816S"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj264"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850113"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-6-200009190-00009"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.6.813"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","unstructured":"Ernst E. Stevinson C. Pittler M. H. Meta\u2010analyses of garlic for hypercholesterolemia in: Schulz VII Rietbrock N. Roots I. Loew D. (Eds.)Phytopharmaka VII. 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